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http://hdl.handle.net/2445/174259
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DC Field | Value | Language |
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dc.contributor.author | Mothe, Beatriz | - |
dc.contributor.author | Rosas-Umbert, Miriam | - |
dc.contributor.author | Coll, Pep | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Puertas Castro, Ma. Carmen | - |
dc.contributor.author | Morón-López, Sara | - |
dc.contributor.author | Llano, Anuska | - |
dc.contributor.author | Miranda, Cristina | - |
dc.contributor.author | Cedeño, Samandhy | - |
dc.contributor.author | López, Miriam | - |
dc.contributor.author | Alarcón-Soto, Yovaninna | - |
dc.contributor.author | Gómez Melis, Guadalupe | - |
dc.contributor.author | Langohr, Klaus | - |
dc.contributor.author | Barriocanal, Ana M. | - |
dc.contributor.author | Toro, Jessica | - |
dc.contributor.author | Ruiz, Irene | - |
dc.contributor.author | Rovira, Cristina | - |
dc.contributor.author | Carrillo, Antonio | - |
dc.contributor.author | Meulbroek, Michael | - |
dc.contributor.author | Crook, Alison | - |
dc.contributor.author | Wee, Edmund G. | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Valle, Marta | - |
dc.contributor.author | Martínez Picado, Francisco Javier | - |
dc.contributor.author | Hanke, Tomás | - |
dc.contributor.author | Brander, Christian | - |
dc.contributor.author | Moltó, José | - |
dc.contributor.author | B.C.N02 Study Investigators | - |
dc.date.accessioned | 2021-02-24T16:48:02Z | - |
dc.date.available | 2021-02-24T16:48:02Z | - |
dc.date.issued | 2020-05-06 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174259 | - |
dc.description.abstract | Kick&kill strategies combining drugs aiming to reactivate the viral reservoir with therapeutic vaccines to induce effective cytotoxic immune responses hold potential to achieve a functional cure for HIV-1 infection. Here, we report on an open-label, single-arm, phase I clinical trial, enrolling 15 early-treated HIV-1-infected individuals, testing the combination of the histone deacetylase inhibitor romidepsin as a latency-reversing agent and the MVA.HIVconsv vaccine. Romidepsin treatment resulted in increased histone acetylation, cell-associated HIV-1 RNA, and T-cell activation, which were associated with a marginally significant reduction of the viral reservoir. Vaccinations boosted robust and broad HIVconsv-specific T cells, which were strongly refocused toward conserved regions of the HIV-1 proteome. During a monitored ART interruption phase using plasma viral load over 2,000 copies/ml as a criterium for ART resumption, 23% of individuals showed sustained suppression of viremia up to 32 weeks without evidence for reseeding the viral reservoir. Results from this pilot study show that the combined kick&kill intervention was safe and suggest a role for this strategy in achieving an immune-driven durable viremic control. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.00823 | - |
dc.relation.ispartof | Frontiers in Immunology, 2020, vol. 11, num. 823 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2020.00823 | - |
dc.rights | cc-by (c) Mothe, Beatriz et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Vacunació | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Vaccination | - |
dc.title | HIVconsv Vaccines and Romidepsin in Early-Treated HIV-1-Infected Individuals: Safety, Immunogenicity and Effect on the Viral Reservoir (Study BCN02) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 701544 | - |
dc.date.updated | 2021-02-24T16:48:02Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/681137/EU//EAVI2020 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32435247 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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701544.pdf | 3.43 MB | Adobe PDF | View/Open |
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