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Title: ERBB2mRNA expression and response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-positive breast cancer
Author: Griguolo, Gaia
Brasó Maristany, Fara
Gonzalez Farré, Blanca
Pascual, Tomás
Chic, Núria
Saurí, Tamara
Kates, Ronald
Gluz, Oleg
Martínez, Débora
Paré, Laia
Tsvetkova, Vassilena
Pesantez, David
Vidal Losada, Maria Jesús
Adamo, Barbara
Muñoz Mateu, Montserrat
Galván, Patricia
Barberá, Laura
Cuatrecasas Freixas, Miriam
Christgen, Mathias
Kreipe, Hans
Monge Escartín, Inés
Villagrasa, Patricia
Soy Muner, Dolors
Giarratano, Tommaso
Dieci, Maria Vittoria
Conte, Pierfranco
Harbeck, Nadia
Guarneri, Valentina
Prat Aparicio, Aleix
Keywords: Càncer de mama
Receptors d'hormones
Breast cancer
Hormone receptors
Issue Date: 14-Jul-2020
Publisher: MDPI
Abstract: Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA.We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed para n-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally,
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It is part of: Cancers, 2020, vol. 12(7), num. 1902
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ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Medicina)

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