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Title: Role of CPI-17 in restoring skin homoeostasis in cutaneous field of cancerization: effects of topical application of a film-forming medical device containing photolyase and UV filters
Author: Puig Butillé, Joan Anton
Malvehy, J. (Josep)
Potrony Mateu, Míriam
Trullas, Carles
García García, Francisco
Dopazo, Joaquín
Puig i Sardà, Susana
Keywords: Càncer de pell
Skin cancer
Pathological histology
Issue Date: 23-May-2013
Publisher: John Wiley & Sons
Abstract: Cutaneous field of cancerization (CFC) is caused in part by the carcinogenic effect of the cyclobutane pyrimidine dimers CPD and 6‐4 photoproducts (6‐4PPs). Photoreactivation is carried out by photolyases which specifically recognize and repair both photoproducts. The study evaluates the molecular effects of topical application of a film‐forming medical device containing photolyase and UV filters on the precancerous field in AK from seven patients. Skin improvement after treatment was confirmed in all patients by histopathological and molecular assessment. A gene set analysis showed that skin recovery was associated with biological processes involved in tissue homoeostasis and cell maintenance. The CFC response was associated with over‐expression of the CPI‐17 gene, and a dependence on the initial expression level was observed (P = 0.001). Low CPI‐17 levels were directly associated with pro‐inflammatory genes such as TNF (P = 0.012) and IL‐1B (P = 0.07). Our results suggest a role for CPI‐17 in restoring skin homoeostasis in CFC lesions.
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It is part of: Experimental Dermatology, 2013, vol. 22, num. 7, p. 494-496
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ISSN: 0906-6705
Appears in Collections:Articles publicats en revistes (Medicina)

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