Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/174289
Title: | Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease |
Author: | Díaz Garrido, Natalia Cordero, Cecilia Olivo-Martinez, Yenifer Badía Palacín, Josefa Baldomà Llavinés, Laura |
Keywords: | Mucosa gastrointestinal Intestins Cèl·lules epitelials Gastrointestinal mucosa Intestines Epithelial cells |
Issue Date: | 23-Feb-2021 |
Publisher: | MDPI |
Abstract: | Communication between cells is crucial to preserve body homeostasis and health. Tightly controlled intercellular dialog is particularly relevant in the gut, where cells of the intestinal mucosa are constantly exposed to millions of microbes that have great impact on intestinal homeostasis by controlling barrier and immune functions. Recent knowledge involves extracellular vesicles (EVs) as mediators of such communication by transferring messenger bioactive molecules including proteins, lipids, and miRNAs between cells and tissues. The specific functions of EVs principally depend on the internal cargo, which upon delivery to target cells trigger signal events that modulate cellular functions. The vesicular cargo is greatly influenced by genetic, pathological, and environmental factors. This finding provides the basis for investigating potential clinical applications of EVs as therapeutic targets or diagnostic biomarkers. Here, we review current knowledge on the biogenesis and cargo composition of EVs in general terms. We then focus the attention to EVs released by cells of the intestinal mucosa and their impact on intestinal homeostasis in health and disease. We specifically highlight their role on epithelial barrier integrity, wound healing of epithelial cells, immunity, and microbiota shaping. Microbiota-derived EVs are not reviewed here. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22042213 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num. 4, p. 2213 |
URI: | https://hdl.handle.net/2445/174289 |
Related resource: | https://doi.org/10.3390/ijms22042213 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
707307.pdf | 2.31 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License