Please use this identifier to cite or link to this item:
Title: Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model
Author: Griñán Ferré, Christian
Corpas Expósito, Rubén
Puigoriol Illamola, Dolors
Palomera Ávalos, Verónica
Sanfeliu i Pujol, Coral
Pallàs i Llibería, Mercè, 1964-
Keywords: Malaltia d'Alzheimer
Malalties neurodegeneratives
Alzheimer's disease
Neurodegenerative Diseases
Issue Date: 2-Apr-2018
Publisher: IOS Press
Abstract: Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD. Keywords: Aging, DNA methylation, epigenetics, histone modification, neurodegeneration
Note: Reproducció del document publicat a:
It is part of: Journal of Alzheimer's Disease, 2018, vol. 62, num. 3, p. 943-963
Related resource:
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
680647.pdf165 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.