Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/174290
Title: | Understanding Epigenetics in the Neurodegeneration of Alzheimer's Disease: SAMP8 Mouse Model |
Author: | Griñán Ferré, Christian Corpas Expósito, Rubén Puigoriol Illamola, Dolors Palomera Ávalos, Verónica Sanfeliu i Pujol, Coral Pallàs i Llibería, Mercè, 1964- |
Keywords: | Malaltia d'Alzheimer Malalties neurodegeneratives Envelliment Epigenètica Alzheimer's disease Neurodegenerative Diseases Aging Epigenetics |
Issue Date: | 2-Apr-2018 |
Publisher: | IOS Press |
Abstract: | Epigenetics is emerging as the missing link among genetic inheritance, environmental influences, and body and brain health status. In the brain, specific changes in nucleic acids or their associated proteins in neurons and glial cells might imprint differential patterns of gene activation that will favor either cognitive enhancement or cognitive loss for more than one generation. Furthermore, derangement of age-related epigenetic signaling is appearing as a significant risk factor for illnesses of aging, including neurodegeneration and Alzheimer's disease (AD). In addition, better knowledge of epigenetic mechanisms might provide hints and clues in the triggering and progression of AD. Intense research in experimental models suggests that molecular interventions for modulating epigenetic mechanisms might have therapeutic applications to promote cognitive maintenance through an advanced age. The SAMP8 mouse is a senescence model with AD traits in which the study of epigenetic alterations may unveil epigenetic therapies against the AD. Keywords: Aging, DNA methylation, epigenetics, histone modification, neurodegeneration |
Note: | Reproducció del document publicat a: https://doi.org/10.3233/JAD-170664 |
It is part of: | Journal of Alzheimer's Disease, 2018, vol. 62, num. 3, p. 943-963 |
URI: | https://hdl.handle.net/2445/174290 |
Related resource: | https://doi.org/10.3233/JAD-170664 |
ISSN: | 1387-2877 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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