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Title: Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort
Author: Idahl, Annika
Cornet, Charlotte Le
González Maldonado, Sandra
Waterboer, Tim
Bender, Noemi
Tjønneland, Anne
Hansen, Louise
Boutron-Ruault, Marie-Christine
Fournier, Agnès
Kvaskoff, Marina
Boeing, Heiner
Trichopoulou, Antonia
Valanou, Elisavet
Peppa, Eleni
Palli, Domenico
Agnoli, Claudia
Mattiello, Amalia
Tumino, Rosario
Sacerdote, Carlotta
Onland-Moret, N. Charlotte
Gram, Inger T.
Weiderpass, Elisabete
Quirós, J. Ramón
Duell, Eric J.
Sánchez, Maria José
Chirlaque, María Dolores
Barricarte, Aurelio
Gil, Leire
Brändstedt, Jenny
Riesbeck, Kristian
Lundin, Eva
Khaw, Kay‐Tee
Pérez Cornago, Aurora
Gunter, Marc J.
Dossus, Laure
Kaaks, Rudolf
Fortner, Renée T.
Keywords: Càncer d'ovari
Malalties de transmissió sexual
Ovarian cancer
Sexually transmitted diseases
Issue Date: 24-Apr-2020
Publisher: John Wiley & Sons Ltd.
Abstract: A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.
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It is part of: International Journal of Cancer, 2020, vol. 147, num. 8, p. 2042-2052
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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