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http://hdl.handle.net/2445/174366
Title: | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
Author: | Linares, Jenniffer Marín Jiménez, Juan A. Badia Ramentol, Jordi Calon, Alexandre |
Keywords: | Càncer Tractament adjuvant del càncer Metàstasi Cancer Adjuvant treatment of cancer Metastasis |
Issue Date: | 22-Jan-2021 |
Publisher: | Frontiers Media |
Abstract: | Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fcell.2020.621070 |
It is part of: | Frontiers in Cell and Developmental Biology, 2021, vol. 8 |
URI: | http://hdl.handle.net/2445/174366 |
Related resource: | https://doi.org/10.3389/fcell.2020.621070 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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fcell-08-621070.pdf | 2.04 MB | Adobe PDF | View/Open |
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