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Title: The Value of Mouse Models of Rare Diseases: A Spanish Experience
Author: Murillo Cuesta, Silvia
Artuch Iriberri, Rafael
Asensio, Fernando
Villa, Pedro de la
Dierssen, Mara
Enriquez, Jose Antonio
Fillat i Fonts, Cristina
Fourcade, Stéphane
Ibánez, Borja
Montoliu, Lluis
Oliver, Eduardo
Pujol Onofre, Aurora
Salido, Eduardo
Vallejo, Mario
Varela Nieto, Isabel
Working Group on Animal Models of Rare Diseases
Networking Center for Rare Diseases (CIBERER)
Keywords: Malalties rares
Models animals en la investigació
Rare diseases
Animal models in research
Issue Date: 14-Oct-2020
Publisher: Frontiers Media
Abstract: Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and greatly contribute to accelerate the development of new therapeutic options for rare diseases. Despite this, the use of experimental animals remains controversial. The combination of respectful management, ethical laws and transparency regarding animal experimentation contributes to improve society's opinion about biomedical research and positively impacts on research quality, which eventually also benefits patients. Here we present examples of current advances in preclinical research in rare diseases using mouse models, together with our perspective on future directions and challenges.
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It is part of: Frontiers in Genetics, 2020, vol. 11
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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