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Title: | Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort |
Author: | Fortner, Renée T. Hüsing, Anika Dossus, Laure Tjønneland, Anne Overvad, Kim Dahm, Christina C. Arveux, Patrick Fournier, Agnès Kvaskoff, Marina Schulze, Matthias B. Bergmann, Manuela M. Trichopoulou, Antonia Karakatsani, Anna Vecchia, Carlo La Masala, Giovanna Pala, Valeria Mattiello, Amalia Tumino, Rosario Ricceri, Fulvio Gils, Carla H. Monninkhof, Evelyn M. Bonet Bonet, Catalina Quirós, J. Ramón Sánchez Pérez, María José Rodríguez Palacios, Daniel Ángel Barricarte, Aurelio Amiano, Pilar Allen, Naomi E. Travis, Ruth C. Gunter, Marc J. Viallon, Vivian Weiderpass, Elisabete Riboli, Elio Kaaks, Rudolf |
Keywords: | Càncer d'endometri Pes corporal Hormonoteràpia Endometrial cancer Body weight Hormone therapy |
Issue Date: | 18-Feb-2020 |
Publisher: | Wiley & Sons Ltd. |
Abstract: | Endometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m2 ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned, but not readily modifiable). Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT use (to all non-HT users) profiles resulted in a 30% reduction in predicted EC incidence rates; individually, longer duration of OC use (to all ≥10 years) resulted in a 42.5% reduction. Modeled changes in not readily modifiable exposures (i.e., those not contributing to prevention potential) resulted in ≤24.6% reduction in predicted EC incidence. Women in the lowest decile of a risk score based on the evaluated exposures had risk similar to a low risk countries; however, this was driven by relatively long use of OCs (median = 23 years). Our findings support avoidance of overweight BMI and of HT use as prevention strategies for EC in a European population; OC use must be considered in the context of benefits and risks. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ijc.32901 |
It is part of: | International Journal of Cancer, 2020, vol. 147, num. 5, p. 1325-1333 |
URI: | http://hdl.handle.net/2445/174400 |
Related resource: | https://doi.org/10.1002/ijc.32901 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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