Please use this identifier to cite or link to this item:
Title: The use and adherence of oral anticoagulants in Primary Health Care in Catalunya, Spain: A real-world data cohort study
Author: Giner Soriano, Maria
Cortes, Jordi
Gomez Lumbreras, Ainhoa
Prat Vallverdú, Oriol
Quijada Manuitt, M. Angeles
Morros Pedrós, Rosa
Keywords: Assistència primària
Fibril·lació auricular
Anticoagulants (Medicina)
Primary care
Atrial fibrillation
Anticoagulants (Medicine)
Issue Date: 1-Oct-2020
Publisher: Elsevier España, S. L. U.
Abstract: Objective: We aimed to describe sociodemographic, comorbidities, co-medication and risk of thromboembolic events and bleeding in patients with NVAF initiating oral anticoagulants (OAC) for stroke prevention, and to estimate adherence and persistence to OAC. Setting: Primary Health Care (PHC) in the Catalan Health Institute (ICS), Catalunya, Spain. Participants: All NVAF adult patients initiating OAC for stroke prevention in August 2013-December 2015. Methods: Population-based cohort study. Persistence was measured in patients initiating OAC in August 2013-December 2014. Data source: SIDIAP, which captures electronic health records from PHC in the (ICS), covering approximately 5.8 million people. Results: 51,690 NVAF patients initiated OAC; 47,197 (91.3%) were naive to OAC and 32,404 (62.7%) initiated acenocoumarol. Mean age was 72.8 years (SD 12.3) and 49.4% were women. Platelet-aggregation inhibitors were taken by 9105 (17.6%) of the patients. Persistence and adherence were estimated up to the end of follow-up. For 22,075 patients, persistence was higher among the non-naive patients [n = 258 (61.7%)] than among the naive [n = 11,502 (53.1%)]. Adherence was estimated for patients initiating DOAC and it was similar in naive and non-naive patients. Among the naive to DOAC treatment, those starting rivaroxaban showed a highest proportion [(n = 360 (80.1%)] of good adherence at implementation (MPR > 80%) while patients starting dabigatran were less adherent [n=203 (47.8%)]. Conclusions: Acenocoumarol was the most frequently prescribed OAC as first therapy in NVAF patients. Non-naive to DOAC showed better persistence than naive. Rivaroxaban showed higher proportion of adherent patients during the implementation phase than apixaban and dabigatran the lowest. (C) 2020 The Authors. Published by Elsevier Espana, S.L.U.
Note: Reproducció del document publicat a:
It is part of: Atención Primaria, 2020, vol. 52, num. 8, p. 529-538
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
Giner-SorianoM.pdf962.69 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons