Title: | Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years |
Author: | Dima, Danai Modabbernia, Amirhossein Papachristou, Efstathios Doucet, Gaelle E. Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N. Albajes Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I. Andersson, Micael Rosa, Pedro G. P. Gruber, Oliver Gruner, Patricia Trollor, Julian N. Gur, Rachel E. Nordvik, Jan E. Stein, Dan J. Pergola, Giulio Yoncheva, Yulyia Buckner, Randy L. Espeseth, Thomas Lesch, Klaus-Peter Gur, Ruben C. Frodl, Thomas Lebedeva, Irina West, John D. Heslenfeld, Dirk J. Wang, Lei Hulshoff Pol, Hilleke E. Walter, Henrik Satterthwaite, Theodore D. Haren, Neeltje E. M. Crone, Eveline A. Uhlmann, Anne Huyser, Chaim Hartman, Catharine A. McMahon, Katie L. Jiang, Jiyang Ho, Beng Choon Kanai, Ryota Baumeister, Sarah Klein, Marieke Ent, Dennis Andreasen, Nancy C. Lochner, Christine Thompson, Paul M. Tordesillas Gutiérrez, Diana Wolf, Daniel H. Franke, Barbara Westlye, Lars T. Machielsen, Marise W. J. Joska, John A. Pomarol-Clotet, Edith Cannon, Dara M. Mataix Cols, David Busatto, Geraldo F. McPhilemy, Genevieve Völzke, Henry Menchón Magriñá, José Manuel Worker, Amanda Medland, Sarah E. Meyer Lindenberg, Andreas Hohmann, Sarah Weber, Bernd Erp, Theo G. M. Brodaty, Henry Hickie, Ian B. Baur Streubel, Ramona Naaijen, Jilly Mcdonald, Colm Schmaal, Lianne Kuntsi, Jonna Nyberg, Lars Crivello, Fabrice Portella, Maria J. Grimm, Oliver Ziegler, Georg C. Potkin, Steven G. Gotlib, Ian H. Radua, Joaquim Reif, Andreas Geus, Eco J. C. Banaschewski, Tobias Wright, Margaret J. Conrod, Patricia Koenders, Laura Harrison, Ben J. Wierenga, Lara M. Rinker, Daniel A. Ortiz‐García Foz, Víctor Heuvel, Odile A. Brouwer, Rachel M. Sachdev, Perminder S. Fouche, Jean Paul Schnell, Knut Fatouros Bergman, Helena Canales Rodríguez, Erick Jorge Haan, Lieuwe de Schumann, Gunter Holmes, Avram J. Sim, Kang Smoller, Jordan W. Glahn, David C. Sommer, Iris Buitelaar, Jan K. Erk, Susanne Caseras, Xavier Jönsson, Erik G. Mazoyer, Bernard Bonvino, Aurora Soriano‐mas, Carles Sarró, Salvador Whalley, Heather Conzelmann, Annette Tamnes, Christian K. Hibar, Derrek P. Meer, Dennis Heinz, Andreas Davey, Christopher Oosterlaan, Jaap Castellanos, Francisco X. Wee, Nic J. A. Strike, Lachlan T. Boomsma, Dorret I. Veer, Ilya M. Tomyshev, Alexander S. Bertolino, Alessandro Lagopoulos, Jim Walton, Esther Klyushnik, Tatyana P. Williams, Steven C. R. Kalnin, Andrew Fuentes Claramonte, Paola Jahanshad, Neda Sánchez Juan, Pascual Hoogman, Martine Wittfeld, Katharina Voineskos, Aristotle Grabe, Hans Jörgen Yang, Kun Wassink, Thomas H. Frangou, Sophia Hatton, Sean N. Borgwardt, Stefan James, Anthony Bourque, Josiane Hoekstra, Pieter J. Mcintosh, Andrew M. Brandeis, Daniel Maingault, Sophie Thomopoulos, Sophia I. Lázaro, Luisa Breier, Alan Zanetti, Marcus V. Zubicaray, Greig I. Wen, Wei Koops, Sanne Asherson, Philip Cervenka, Simon Kahn, Rene Chaim-Avancini, Tiffany M. Martin, Nicholas G. Ching, Christopher R. K. Krämer, Bernd Pauli, Paul Chubar, Victoria Jernigan, Terry L. Najt, Pablo Wang, Yang Howells, Fleur M. Clark, Vincent P. Calhoun, Vincent Crespo Facorro, Benedicto Bargalló Alabart, Núria Karolinska Schizophrenia Project (KaSP) Salvador, Raymond Braber, Anouk Sacchet, Matthew D. Mcdonald, Brenna C. Dickie, Erin W. Nakao, Tomohiro Di Giorgio, Annabella Doan, Nhat Trung Saykin, Andrew J. Dørum, Erlend S. Martínez Zalacaín, Ignacio Roffman, Joshua L. Andreassen, Ole A. Veltman, Dick J. Lee, Won Hee Ehrlich, Stefan Dale, Anders M. Hosten, Norbert Turner, Jessica A. Fisher, Simon E. Temmingh, Henk S. Groenewold, Nynke A. Swagerman, Suzanne C. Paloyelis, Yannis Serpa, Mauricio H. Grotegerd, Dominik |
Keywords: | Cervell Edat Morfologia (Biologia) Brain Age Morphology (Biology) |
Issue Date: | 11-Feb-2021 |
Publisher: | Wiley |
Abstract: | Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3-90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/hbm.25320 |
It is part of: | Human Brain Mapping, 2022, vol.43, num. 1, p. 452-469 |
URI: | http://hdl.handle.net/2445/174582 |
Related resource: | https://doi.org/10.1002/hbm.25320 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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