Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/174670
Title: | Enfermedad de Paget extramamaria |
Author: | Marcoval Caus, Joaquim Penín, Rosa Vidal Alabró, Anna Bermejo Martín, Jesús |
Keywords: | Càncer Patologia Cancer Pathology |
Issue Date: | 1-May-2020 |
Publisher: | Elsevier España, S.L.U. |
Abstract: | Background and objective: Extramammary Paget disease (EMPD) has seldom been studied in Mediterranean populations. We aimed to review the characteristics of our patients with EMPD, the presence of a neoplasm in continuity, and the long-term course of the disease. Patients and methods: Retrospective observational study of 27 patients diagnosed with EMPD between 1990 and 2015. All clinical and pathology findings related to clinical course and outcomes were retrieved for analysis. Results: Twenty patients were women and 7 were men. Ages ranged from 42 to 88 years (median, 76 years). Lesions were in the following locations: vulva (16 cases), pubis-groin (5), perianal region (4), and axilla (2). Time from onset to diagnosis ranged from 1 to 60 months (median, 12 months) and maximum lesion diameter from 20 to 140mm (median, 55mm). In 3 cases (11.1%) EMPD was a secondary condition. None of the lesions developed on a previous cutaneous adnexal adenocarcinoma. Ten of the 24 primary EMPDs (41.7%) invaded the dermis. Eight of the 27 patients (29.6%) experienced local recurrence after the initial surgical treatment.Three patients (11.1%) died as a consequence of metastasis from the EMPD. Conclusions: The presence of an underlying cutaneous adnexal adenocarcinoma is uncommon, but it is not unusual to find an extracutaneous adenocarcinoma in continuity. Although EMPD is a slow-growing tumor, dermal invasion is frequent and metastasis is not uncommon. Local recurrence is common even after excision with wide margins and may be delated, so long term follow-up is essential. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.ad.2019.09.003 |
It is part of: | Actas Dermo-Sifiliográficas, 2020, vol. 111, num. 4, p. 306-312 |
URI: | http://hdl.handle.net/2445/174670 |
Related resource: | https://doi.org/10.1016/j.ad.2019.09.003 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Enfermedad_de_Paget_extramamaria.pdf | 1.57 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License