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Title: Duodenal adenomas and cancer in MUTYH-associated polyposis: an international cohort study
Author: Collaborative Group on Duodenal Polyposis in MAP
Thomas, Laura E.
Hurley, Joanna J.
Alonso Sánchez, Ángel
Aznárez, M. Rosario
Backman, Ann Sofie
Bjork, Jan
Capellá, G. (Gabriel)
Clark, Susan K.
Colas, Chrystelle
Dekker, Evelien
Dolwani, Sunil
Ghorbanoghli, Zeinab
Gonn, Mark
González Romero, S.
Hes, Frederik J.
Jundi, Hala
Kelland, Sarah
Latchford, Andrew R.
Leon Brito, Helena
Lynch, Patrick M.
Meuser, Elena
Mork, Maureen E.
Mort, Matthew
Navarro García, Matilde
Nielsen, Maartje
Parc, Yann
Ricci, Maria T.
Saurin, Jean Christophe
van der Tuin, Karin
Vasen, Hans
Vilar, Eduardo
Vinet, Olivier
Vitellaro, Marco
Walton, Sarah Jane
West, Hannah D.
Sampson, Julian R.
Keywords: Endoscòpia
Estudi de casos
Case studies
Issue Date: 1-Feb-2021
Publisher: Elsevier
Abstract: Although duodenal adenomas and cancer appear to occur significantly less frequently in autosomal recessive MUTYH-associated polyposis (MAP) than in autosomal dominant familial adenomatous polyposis (FAP),1 current guidelines recommend similar endoscopic surveillance for both disorders.2-4 This involves gastro-duodenoscopy starting at 25 to 35 years of age and repeated at intervals determined by Spigelman staging based on the number, size, histological type and degree of dysplasia of adenomas, and by ampullary staging. Case reports of duodenal cancers in MAP suggest that they may develop in the absence of advanced Spigelman stage benign disease and even without coexisting adenomas.1 Recent molecular analyses suggest thatMAPduodenal adenomashave a higher mutational burden than FAP adenomas and are more likely to harbor oncogenic drivermutations, such as those in KRAS.5 These apparent differences in the biology and natural history of duodenal polyposis in FAP and MAP challenge the assumption that the same surveillance should be applied in both conditions.
Note: Reproducció del document publicat a:
It is part of: Gastroenterology, 2021, vol. 160, num. 3, p. 952-954
Related resource:
ISSN: 0016-5085
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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