Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/174864
Title: | Efficacy and safety of direct-acting antiviral agents when combined with secukinumab |
Author: | Martínez Santana, Virginia Rodríguez Murphy, Esther Smithson Amat, Alejandro Miserachs Aranda, Nuria Río-Gil, Ruben del Torre Lloverás, Inmaculada |
Keywords: | Hepatitis C Malalties autoimmunitàries Interaccions dels medicaments Hepatitis C Autoimmune diseases Drug interactions |
Issue Date: | 20-May-2017 |
Abstract: | Background: The interference in the immune response induced by biological disease-modifying antirheumatic drugs (bDMARDs) increases the risk of reactivation of infections. Treatment of patients with chronic hepatitis C virus (HCV) infection and psoriasis is complex. The efficacy and safety of the new direct-acting antiviral agents (DAA) when combined with bDMARDs remain unknown. Case report: We present a case of a 44-year-old Caucasian man affected with psoriasis and HCV infection. Throughout the course of the psoriatic disease, this patient received several lines of treatment, including secukinumab, a new type of bDMARD. At the time of commencing secukinumab, new DAA agents (ledipasvir/sofosbuvir) were also initiated. At week 12 post-treatment, hepatitis C viral load was undetectable and the patient remained in remission of psoriasis. Conclusion: This case report suggests that secukinumab is a therapeutic option in patients with psoriasis, particularly in those cases with HCV infection where treatment with DAA agents is warranted. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/ejhpharm-2017-001212 |
It is part of: | European Journal Of Hospital Pharmacy-Science And Practice, 2018, vol. 25, num. 1, p. 53-56 |
URI: | https://hdl.handle.net/2445/174864 |
Related resource: | https://doi.org/10.1136/ejhpharm-2017-001212 |
ISSN: | 2047-9956 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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