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Title: Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease
Author: Griñán Ferré, Christian
Codony Gisbert, Sandra
Pujol Bech, Eugènia
Yang, Jun
Leiva Martínez, Rosana
Escolano Mirón, Carmen
Puigoriol Illamola, Dolors
Companys Alemany, Júlia
Corpas Expósito, Rubén
Sanfeliu i Pujol, Coral
Pérez, Belén
Loza, María Isabel
Brea, José
Morisseau, Christophe
Hammock, Bruce D.
Vázquez Cruz, Santiago
Pallàs i Llibería, Mercè, 1964-
Galdeano Cantador, Carlos
Keywords: Malaltia d'Alzheimer
Malalties neurodegeneratives
Alzheimer's disease
Neurodegenerative Diseases
Issue Date: 2-Jun-2020
Publisher: Springer Verlag
Abstract: The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical therapeutic effects in several peripheral inflammatory-related diseases, with three compounds in clinical trials. However, the role of this enzyme in the neuroinflammation process has been largely neglected. Herein, we disclose the pharmacological validation of sEH as a novel target for the treatment of Alzheimer's Disease (AD). Evaluation of cognitive impairment and pathological hallmarks were used in two models of age-related cognitive decline and AD using three structurally different and potent sEH inhibitors as chemical probes. sEH is upregulated in brains from AD patients. Our findings supported the beneficial effects of central sEH inhibition, regarding reducing cognitive impairment, neuroinflammation, tau hyperphosphorylation pathology and the number of amyloid plaques. This study suggests that inhibition of inflammation in the brain by targeting sEH is a relevant therapeutic strategy for AD.
Note: Versió postprint del document publicat a:
It is part of: Neurotherapeutics, 2020
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ISSN: 1933-7213
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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