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Title: Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications
Author: Almanza, Aitor
Carlesso, Antonio
Chintha, Chetan
Creedican, Stuart
Doultsinos, Dimitrios
Leuzzi, Brian
Luís, Andreia
Mccarthy, Nicole
Montibeller, Luigi
More, Sanket
Papaioannou, Alexandra
Püschel, Franziska
Sassano, Maria Livia
Skoko, Josip
Agostinis, Patrizia
Belleroche, Jackie de
Eriksson, Leif A.
Fulda, Simone
Gorman, Adrienne M.
Healy, Sandra
Kozlov, Andrey
Muñoz Pinedo, Cristina
Rehm, Markus
Chevet, Eric
Samali, Afshin
Keywords: Reticle endoplasmàtic
Endoplasmic reticulum
Issue Date: 4-Aug-2018
Publisher: Wiley
Abstract: The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.
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It is part of: The FEBS Journal, 2018, vol. 286, num. 2, p. 241-278
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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