Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/175091
Title: | Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies |
Author: | Jayasekara, Harindra MacInnis, Robert J. Luján Barroso, Leila Mayen Chacon, Ana Lucia Cross, Amanda J. Wallner, Bengt Palli, Domenico Ricceri, Fulvio Pala, Valeria Panico, Salvatore Tumino, Rosario Kühn, Tilman Kaaks, Rudolf Tsilidis, Kostas Sánchez, María José Amiano, Pilar Ardanaz, Eva Chirlaque, María Dolores Merino, Susana Rothwell, Joseph A. Boutron-Ruault, Marie-Christine Severi, Gianluca Sternby, Hanna Sonestedt, Emily Bueno de Mesquita, H. Bas Boeing, Heiner Travis, Ruth Sandanger, Torkjel M. Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Tjønneland, Anne Yang, Yi Hodge, Allison M. Mitchell, Hazel Haydon, Andrew Room, Robin Hopper, John L. Weiderpass, Elisabete Gunter, Marc J. Riboli, Elio Giles, Graham G. Milne, Roger L. Agudo, Antonio English, Dallas R. Ferrari, Pietro |
Keywords: | Consum d'alcohol Càncer d'estómac Drinking of alcoholic beverages Stomach cancer |
Issue Date: | 22-Feb-2021 |
Publisher: | John Wiley & Sons Ltd. |
Abstract: | Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ijc.33504 |
It is part of: | International Journal of Cancer, 2021 |
URI: | https://hdl.handle.net/2445/175091 |
Related resource: | https://doi.org/10.1002/ijc.33504 |
Appears in Collections: | Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ijc.33504.pdf | 993.49 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License