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http://hdl.handle.net/2445/175175
Title: | Spleen rupture in a case of untreated Plasmodium vivax infection |
Author: | Machado Siqueira, André Lopes Magalhães, Belisa Maria Cardoso de Melo, Gisely Ferrer, Mireia Castillo, Paola Martín Jaular, Lorena Fernández Becerra, Carmen Ordi i Majà, Jaume Martínez, Antonio Guimarães Lacerda, Marcus Vinícius Portillo Obando, Hernando A. del |
Keywords: | Plasmodium vivax Malalties parasitàries Malària Plasmodium vivax Parasitic diseases Malaria |
Issue Date: | 13-Dec-2012 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | We report the unique case of a 19-yearold nonimmune patient with Plasmodium vivax monoinfection, confirmed by PCR in the peripheral blood and in the spleen section, who was splenectomized due to spleen rupture two days prior to the diagnosis and treatment of the malarial infection. Microscopic analyses evidenced white pulp expansion and a diffuse hypercellularity in the splenic red pulp, with intense proliferating plasmablasts in the subcapsular and perivascular compartments as well as large numbers of intact P. vivax-infected reticulocytes in the cords, in the absence of other concomitant infectious diseases. To our knowledge, this is the first full detailed immunohistopathological characterization of a nontreated P. vivax-infected spleen. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0001934 |
It is part of: | PLoS Neglected Tropical Diseases, 2012, vol. 6, num. 12, p. e1934 |
URI: | http://hdl.handle.net/2445/175175 |
Related resource: | https://doi.org/10.1371/journal.pntd.0001934 |
ISSN: | 1935-2735 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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