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Title: Spleen rupture in a case of untreated Plasmodium vivax infection
Author: Machado Siqueira, André
Lopes Magalhães, Belisa Maria
Cardoso de Melo, Gisely
Ferrer, Mireia
Castillo, Paola
Martín Jaular, Lorena
Fernández Becerra, Carmen
Ordi i Majà, Jaume
Martínez, Antonio
Guimarães Lacerda, Marcus Vinícius
Portillo Obando, Hernando A. del
Keywords: Plasmodium vivax
Malalties parasitàries
Plasmodium vivax
Parasitic diseases
Issue Date: 13-Dec-2012
Publisher: Public Library of Science (PLoS)
Abstract: We report the unique case of a 19-yearold nonimmune patient with Plasmodium vivax monoinfection, confirmed by PCR in the peripheral blood and in the spleen section, who was splenectomized due to spleen rupture two days prior to the diagnosis and treatment of the malarial infection. Microscopic analyses evidenced white pulp expansion and a diffuse hypercellularity in the splenic red pulp, with intense proliferating plasmablasts in the subcapsular and perivascular compartments as well as large numbers of intact P. vivax-infected reticulocytes in the cords, in the absence of other concomitant infectious diseases. To our knowledge, this is the first full detailed immunohistopathological characterization of a nontreated P. vivax-infected spleen.
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It is part of: PLoS Neglected Tropical Diseases, 2012, vol. 6, num. 12, p. e1934
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ISSN: 1935-2735
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

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