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Title: Risk Factors and Outcomes for Late Presentation for HIV-Positive Persons in Europe: Results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE)
Author: Mocroft, Amanda
Lundgren, Jens D.
Sabin, Miriam Lewis
Arminio Monforte, Antonella d'
Brockmeyer, Norbert H.
Casabona, Jordi
Castagna, Antonella
Costagliola, Dominique
Dabis, François
De Wit, Stéphane
Fätkenheuer, Gerd
Furrer, Hansjakob
Johnson, Anne M.
Lazanas, Marios K.
Leport, Catherine
Moreno, Santiago
Obel, Niels
Post, Frank A.
Reekie, Joanne
Reiss, Peter
Sabin, Caroline
Skaletz Rorowski, Adriane
Suarez Lozano, Ignacio
Torti, Carlo
Warszawski, Josiane
Zangerle, Robert
Fabre Colin, Céline
Kjaer, Jesper
Chene, Geneviève
Grarup, Jesper
Kirk, Ole
Collaboration of Observational HIV Epidemiological Research Europe (COHERE)
Keywords: Infeccions per VIH
HIV infections
Issue Date: 3-Sep-2013
Publisher: Public Library of Science (PLoS)
Abstract: Background: Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality. Methods and Findings: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm3 or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June 2011. Logistic regression was used to identify factors associated with LP and Poisson regression to explore the impact on AIDS/death. 84,524 individuals from 23 cohorts in 35 countries contributed data; 45,488 were LP (53.8%). LP was highest in heterosexual males (66.1%), Southern European countries (57.0%), and persons originating from Africa (65.1%). LP decreased from 57.3% in 2000 to 51.7% in 2010/2011 (adjusted odds ratio [aOR] 0.96; 95% CI 0.95-0.97). LP decreased over time in both Central and Northern Europe among homosexual men, and male and female heterosexuals, but increased over time for female heterosexuals and male intravenous drug users (IDUs) from Southern Europe and in male and female IDUs from Eastern Europe. 8,187 AIDS/deaths occurred during 327,003 person-years of follow-up. In the first year after HIV diagnosis, LP was associated with over a 13-fold increased incidence of AIDS/death in Southern Europe (adjusted incidence rate ratio [aIRR] 13.02; 95% CI 8.19-20.70) and over a 6-fold increased rate in Eastern Europe (aIRR 6.64; 95% CI 3.55-12.43). Conclusions: LP has decreased over time across Europe, but remains a significant issue in the region in all HIV exposure groups. LP increased in male IDUs and female heterosexuals from Southern Europe and IDUs in Eastern Europe. LP was associated with an increased rate of AIDS/deaths, particularly in the first year after HIV diagnosis, with significant variation across Europe. Earlier and more widespread testing, timely referrals after testing positive, and improved retention in care strategies are required to further reduce the incidence of LP.
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It is part of: PLoS Medicine, 2013, vol. 10, num. 9, p. e1001510
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ISSN: 1549-1277
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Medicina)

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