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Title: Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
Author: van Duijnhoven, Franzel J. B.
Jenab, Mazda
Hveem, Kristian
Siersema, Peter D.
Fedirko, Veronika
Duell, Eric J.
Kampman, Ellen
Halfweeg, Anouk
van Kranen, Henk J.
van den Ouweland, Jody M. W.
Weiderpass, Elisabete
Murphy, Neil
Langhammer, Arnulf
Ness-Jensen, Eivind
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Cadeau, Claire
Kvaskoff, Marina
Boutron-Ruault, Marie-Christine
Katzke, Verena
Kühn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Kotanidou, Anastasia
Kritikou, Maria
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Panico, Salvatore
Matullo, Giuseppe
Peeters, Petra H. M.
Brustad, Magritt
Olsen, Karina Standahl
Lasheras, Cristina
Obón Santacana, Mireia
Sánchez, María José
Dorronsoro, Miren
Chirlaque, María Dolores
Barricarte, Aurelio
Manjer, Jonas
Almquist, Martin
Renström, Frida
Ye, Weimin
Wareham, Nick
Khaw, Kay-Tee
Bradbury, Kathryn E.
Freisling, Heinz
Aune, Dagfinn
Norat, Teresa
Riboli, Elio
Bueno de Mesquita, H. Bas
Keywords: Càncer de pàncrees
Vitamina D
Pancreas cancer
Vitamin D
Issue Date: 22-Nov-2017
Publisher: John Wiley & Sons Ltd.
Abstract: Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Note: Reproducció del document publicat a:
It is part of: International Journal of Cancer, 2017, vol. 142, num. 6, p. 1189-1201
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Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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