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Title: Modification of natural flavonoids for their use as drugs
Other Titles: Modificació de flavonoides naturals per al seu ús com a medicaments
Author: Ribé Gorchs, Pol
Director/Tutor: Ariza Piquer, Xavier
Keywords: Flavonoides
Síntesi orgànica
Treballs de fi de grau
Organic synthesis
Bachelor's theses
Issue Date: Jan-2021
Abstract: Obesity is a new problem today due to the increased consumption of energy-dense foods along with a sedentary lifestyle. That is why some studies have been carried out to discover new anti-obesity drugs. It has been found that flavones, a type of molecule in the flavonoid family, are important components of many natural plants with important protective effects, such as antioxidant, anti-inflammatory activity against many diseases and the increase of fat burning by different ways depending on the specific molecule. In this work, we have focused on the synthesis and characterization of five chrysin derivates: 5-hydroxy-7-methoxyflavone, 5,7-dimethoxyflavone, 6-bromo-5,7-dimethoxyflavone, 6,8-dibromo-5,7-hydroxyflavone and 6-benzyl-5,7-dimethoxyflavone. These compounds could be useful for the study of browning of fat cells because it is supposed that they allow to convert WAT (white adipose tissue) to BAT (brown adipose tissue) which could help in different diseases and upgrade the fat burning of our bodies
Note: Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2021, Tutor: Xavier Ariza Piquer
Appears in Collections:Treballs Finals de Grau (TFG) - Química

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