Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/175499
Title: Anti-tumor specific T-cell responses induced by oncolytic adenovirus ONCOS-102 in peritoneal mesothelioma mouse model
Author: Kuryk, Lukasz
Møller, Anne Sophie W.
Garofalo, Mariangela
Cerullo, Vincenzo
Pesonen, Sari
Alemany Bonastre, Ramon
Jaderberg, Magnus
Keywords: Adenovirus
Immunoteràpia
Adenoviruses
Immunotherapy
Issue Date: 11-Jun-2018
Publisher: Wiley
Abstract: Oncolytic adenoviral immunotherapy activates the innate immune system with subsequent induction of adaptive tumor-specific immune responses to fight cancer. Hence, oncolytic viruses do not only eradicate cancer cells by direct lysis, but also generate antitumor immune response, allowing for long-lasting cancer control and tumor reduction. Their therapeutic effect can be further enhanced by arming the oncolytic adenovirus with costimulatory transgenes and/or coadministration with other antitumor therapies. ONCOS-102 has already been found to be well tolerated and efficacious against some types of treatment-refractory tumors, including mesothelin-positive ovarian cancer (NCT01598129). It induced local and systemic CD8+ T-cell immunity and upregulated programmed death ligand 1. These results strongly advocate the use of ONCOS-102 in combination with other therapeutic strategies in advanced and refractory tumors, especially those expressing the mesothelin antigen. The in vivo work presented herein describes the ability of the oncolytic adenovirus ONCOS-102 to induce mesothelin-specific T-cells after the administration of the virus in bagg albino (BALB/c) mice with mesothelin-positive tumors. We also demonstrate the effectiveness of the interferon-γ the enzyme-linked immunospot (ELISPOT) assay to detect the induction of T-cells recognizing mesothelin, hexon, and E1A antigens in ONCOS-102-treated mesothelioma-bearing BALB/c mice. Thus, the ELISPOT assay could be useful to monitor the progress of therapy with ONCOS-102.
Note: Reproducció del document publicat a: https://doi.org/10.1002/jmv.25229
It is part of: Journal of Medical Virology, 2018, vol. 90, issue. 10, p. 1669-1673
URI: https://hdl.handle.net/2445/175499
Related resource: https://doi.org/10.1002/jmv.25229
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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