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Title: | A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk |
Author: | Murphy, Neil Achaintre, David Zamora-Ros, Raul Jenab, Mazda Boutron-Ruault, Marie-Christine Carbonnel, Franck Savoye, Isabelle Kaaks, Rudolf Kühn, Tilman Boeing, Heiner Aleksandrova, Krasimira Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Quirós, J. Ramón Sánchez, Maria Jose Altzibar, Jone M. Huerta, José María Barricarte, Aurelio Khaw, Kay‐Tee Bradbury, Kathryn E. Pérez Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni Palli, Domenico Grioni, Sara Tumino, Rosario Sacerdote, Carlotta Panico, Salvatore Bueno de Mesquita, H. Bas Peeters, Petra H. M. Rutegård, Martin Johansson, Ingegerd Freisling, Heinz Noh, Hwayoung Cross, Amanda J. Vineis, Paolo Tsilidis, Kostas Gunter, Marc J. Scalbert, Augustin |
Keywords: | Marcadors bioquímics Càncer colorectal Estudi de casos Polifenols Biochemical markers Colorectal cancer Case studies Polyphenols |
Issue Date: | 11-Jun-2018 |
Publisher: | Wiley |
Abstract: | Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ijc.31563 |
It is part of: | International Journal of Cancer, 2018, vol. 143, issue. 7, p. 1620-1631 |
URI: | http://hdl.handle.net/2445/175514 |
Related resource: | https://doi.org/10.1002/ijc.31563 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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