Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175547
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Marín Aguilera, Mercedes | - |
dc.contributor.author | Jiménez, Natalia | - |
dc.contributor.author | Reig Torras, Oscar | - |
dc.contributor.author | Montalbo Calafell, Ruth | - |
dc.contributor.author | Verma, Ajit K. | - |
dc.contributor.author | Castellano, Giancarlo | - |
dc.contributor.author | Mengual Brichs, Lourdes | - |
dc.contributor.author | Victoria, Iván | - |
dc.contributor.author | Pereira, María V. | - |
dc.contributor.author | Milà Guasch, Maria | - |
dc.contributor.author | García-Recio, Susana | - |
dc.contributor.author | Benítez-Ribas, Daniel | - |
dc.contributor.author | Cabezón, Raquel | - |
dc.contributor.author | González, Azucena | - |
dc.contributor.author | Juan, Manel | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Mellado González, Begoña | - |
dc.date.accessioned | 2021-03-22T17:26:55Z | - |
dc.date.available | 2021-03-22T17:26:55Z | - |
dc.date.issued | 2020-01-14 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175547 | - |
dc.description.abstract | Androgen receptor (AR) signaling remains crucial in castration-resistant prostate cancer (CRPC). Since it is also essential in immune cells, we studied whether the expression of AR full-length (ARFL) and its splicing variant ARV7 in peripheral blood mononuclear cells (PBMC) predicts systemic treatment response in mCRPC in comparison with circulating-tumor cells (CTC). We measured ARFL and ARV7 mRNA in PBMC and CTC from patients prior to receiving abiraterone (AA), enzalutamide (E), or taxanes by a pre-amplification plus quantitative reverse-transcription PCR. They were also tested in LNCaP-ARV7-transfected and in 22RV1 docetaxel-resistant (22RV1DR) cells. We studied 171 PBMC from 136 patients and from 24 non-cancer controls, and 47 CTC from 22 patients. High PBMC ARV7 levels correlated with worse AA/E and better taxane response. In taxane-treated patients high PBMC ARFL also correlated with longer progression-free survival (PFS). High ARV7 and ARFL expression were independently associated with better biochemical-PFS. Conversely, high CTC ARV7 and ARFL correlated with shorter radiological-PFS and overall survival, respectively. High ARV7 in 22RV1DR and LNCaP-ARV7 cells correlated with taxane resistance. In conclusion, ARFL and ARV7 at PBMC or CTC have a different predictive role in the taxane response, suggesting a potential influence of the AR pathway from PBMC in such response modulation. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cells9010203 | - |
dc.relation.ispartof | Cells, 2020, vol. 9, num. 1, p. 203 | - |
dc.relation.uri | https://doi.org/10.3390/cells9010203 | - |
dc.rights | cc-by (c) Marín Aguilera, Mercedes et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Andrògens | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Androgens | - |
dc.title | Androgen receptor and its splicing variant 7 expression in peripheral blood mononuclear cells and in circulating tumor cells in metastatic castration-resistant prostate cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 701714 | - |
dc.date.updated | 2021-03-22T17:26:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31947623 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
701714.pdf | 2.57 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License