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http://hdl.handle.net/2445/175587
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DC Field | Value | Language |
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dc.contributor.author | Quintairos Domenech, Luis | - |
dc.contributor.author | Colom Codina, Helena | - |
dc.contributor.author | Millán, Olga | - |
dc.contributor.author | Fortuna, Virginia | - |
dc.contributor.author | Espinosa, Cristina | - |
dc.contributor.author | Guirado, Lluís | - |
dc.contributor.author | Budde, Klemens | - |
dc.contributor.author | Sommerer, Claudia | - |
dc.contributor.author | Lizana, Ana | - |
dc.contributor.author | López Púa, Yolanda | - |
dc.contributor.author | Brunet i Serra, Mercè | - |
dc.date.accessioned | 2021-03-23T10:12:53Z | - |
dc.date.available | 2021-03-23T10:12:53Z | - |
dc.date.issued | 2021-01-22 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175587 | - |
dc.description.abstract | Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0245880 | - |
dc.relation.ispartof | PLoS One, 2021, vol. 16, num. 1, p. e0245880 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0245880 | - |
dc.rights | cc-by (c) Quintairos, Lluís et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Farmacocinètica | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Pharmacokinetics | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Risk factors in diseases | - |
dc.title | Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707394 | - |
dc.date.updated | 2021-03-23T10:12:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33481955 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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707394.pdf | 1.31 MB | Adobe PDF | View/Open |
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