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http://hdl.handle.net/2445/175619
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DC Field | Value | Language |
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dc.contributor.author | Cerdà, Pau | - |
dc.contributor.author | Ribas, Jesús | - |
dc.contributor.author | Iriarte, Adriana | - |
dc.contributor.author | Mora Luján, José María | - |
dc.contributor.author | Torres, Raquel | - |
dc.contributor.author | Río, Belén del | - |
dc.contributor.author | Jofré, Héctor Ignacio | - |
dc.contributor.author | Ruiz, Yolanda | - |
dc.contributor.author | Huguet, Marta | - |
dc.contributor.author | Fuset, Maria Paz | - |
dc.contributor.author | Martínez Yélamos, Sergio | - |
dc.contributor.author | Santos, Salud | - |
dc.contributor.author | Llecha, Núria | - |
dc.contributor.author | Corbella, Xavier | - |
dc.contributor.author | Riera Mestre, Antoni | - |
dc.date.accessioned | 2021-03-23T11:13:30Z | - |
dc.date.available | 2021-03-23T11:13:30Z | - |
dc.date.issued | 2020-12-28 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175619 | - |
dc.description.abstract | Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with COVID-19. The main objective was to assess clinical and laboratory differences in hospitalized COVID-19 patients according to occurrence of PE. Methods: This retrospective study included all consecutive patients hospitalized with COVID-19 who underwent a computed tomography (CT) angiography for PE clinical suspicion. Clinical data and median blood test results distributed into weekly periods from COVID-19 symptoms onset, were compared between PE and non-PE patients. Results: Ninety-two patients were included, 29 (32%) had PE. PE patients were younger (63.9 (SD 13.7) vs 69.9 (SD 12.5) years). Clinical symptoms and COVID-19 CT features were similar in both groups. PE was diagnosed after a mean of 20.0 (SD 8.6) days from the onset of COVID-19 symptoms. Corticosteroid boluses were more frequently used in PE patients (62% vs. 43%). No patients met ISTH DIC criteria. Any parameter was statistically significant or clinically relevant except for D-Dimer when comparing both groups. Median values [IQR] of D-dimer in PE vs non-PE patients were: week 2 (2010.7 [770.1-11208.9] vs 626.0 [374.0-2382.2]; p = 0.004); week 3 (3893.1 [1388.2-6694.0] vs 1184.4 [461.8-2447.8]; p = 0.003); and week 4 (2736.3 [1202.1-8514.1] vs 1129.1 [542.5-2834.6]; p = 0.01). Median fold-increase of D-dimer between week 1 and 2 differed between groups (6.64 [3.02-23.05] vs 1.57 [0.64-2.71], p = 0.003); ROC curve AUC was 0.879 (p = 0.003) with a sensitivity and specificity for PE of 86% and 80%, respectively. Conclusions: Among hospitalized COVID-19 patients, D-dimer levels are higher at weeks 2, 3 and 4 after COVID-19 symptom onset in patients who develop PE. This difference is more pronounced when the fold increase between weeks 1 and 2 is compared. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0243533 | - |
dc.relation.ispartof | PLoS One, 2020, vol. 15, num. 12, p. e0243533 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0243533 | - |
dc.rights | cc-by (c) Cerdà, Pau et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Embòlia pulmonar | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.classification | Tromboembolisme | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Pulmonary embolism | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.subject.other | Thromboembolism | - |
dc.title | Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708410 | - |
dc.date.updated | 2021-03-23T11:13:30Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33370304 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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708410.pdf | 1.3 MB | Adobe PDF | View/Open |
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