Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/175835
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oñate, Lorena de | - |
dc.contributor.author | Garreta, Elena | - |
dc.contributor.author | Tarantino, Carolina | - |
dc.contributor.author | Martínez Fraiz, Elena | - |
dc.contributor.author | Capilla Campos, Encarnación | - |
dc.contributor.author | Navarro Álvarez, Isabel | - |
dc.contributor.author | Gutiérrez Fruitós, Joaquín | - |
dc.contributor.author | Samitier i Martí, Josep | - |
dc.contributor.author | Campistol Plana, Josep M. | - |
dc.contributor.author | Muñoz-Cánovas, Pura | - |
dc.contributor.author | Montserrat Pulido, Núria | - |
dc.date.accessioned | 2021-03-26T11:23:43Z | - |
dc.date.available | 2021-03-26T11:23:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://hdl.handle.net/2445/175835 | - |
dc.description.abstract | The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmentation, of the function of damaged cells by patientderived differentiated stem cells would provide a novel cell-based therapy for skeletal muscle-related diseases. Since iPSCs resemble human embryonic stem cells (hESCs) in their ability to generate cells of the three germ layers, patient-specific iPSCs offer definitive solutions for the ethical and histo-incompatibility issues related to hESCs. Indeed human iPSC (hiPSC)-based autologous transplantation is heralded as the future of regenerative medicine. Interestingly, during the last years intense research has been published on disease-specific hiPSCs derivation and differentiation into relevant tissues/organs providing a unique scenario for modelling disease progression, to screen patient-specific drugs and enabling immunosupression-free cell replacement therapies. Here, we revise the most relevant findings in skeletal muscle differentiation using mouse and human PSCs. Finally and in an effort to bring iPSC technology to the daily routine of the laboratory, we provide two different protocols for the generation of patient-derived iPSCs. | ca |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | IntechOpen | ca |
dc.relation.isformatof | Reprodució del document publicat a: http://dx.doi.org/10.5772/60902 | - |
dc.relation.ispartof | Chapter 12 in: Sakuma, Kunihiro. 2015. Muscle Cell and Tissue. IntechOpen. ISBN: 978-953-51-4218-8. DOI: DOI: 10.5772/59347 pp: 333-357. | - |
dc.relation.uri | http://dx.doi.org/10.5772/60902 | - |
dc.rights | cc by (c) Oñate, Lorena de et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Llibres / Capítols de llibre (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Cèl·lules mare | cat |
dc.subject.classification | Distròfia muscular | cat |
dc.subject.other | Stem cells | eng |
dc.subject.other | Muscular dystrophy | eng |
dc.title | Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells | ca |
dc.type | info:eu-repo/semantics/bookPart | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 291885 | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Llibres / Capítols de llibre (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
291885.pdf | 771.91 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License