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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lianza, Mariacaterina | - |
| dc.contributor.author | Verdan, Maria Helena | - |
| dc.contributor.author | Andrade, Jean Paulo de | - |
| dc.contributor.author | Poli, Ferruccio | - |
| dc.contributor.author | Almeida, Larissa C. de | - |
| dc.contributor.author | Costa-Lotufo, Leticia V. | - |
| dc.contributor.author | Cunha Neto, Álvaro | - |
| dc.contributor.author | Oliveira, Sarah C. C. | - |
| dc.contributor.author | Bastida Armengol, Jaume | - |
| dc.contributor.author | Batista, Andrea N. L. | - |
| dc.contributor.author | Batista Jr, João M. | - |
| dc.contributor.author | Borges, Warley S. | - |
| dc.date.accessioned | 2021-04-01T11:33:42Z | - |
| dc.date.available | 2021-04-01T11:33:42Z | - |
| dc.date.issued | 2020-06-01 | - |
| dc.identifier.issn | 0103-5053 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/175967 | - |
| dc.description.abstract | The phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in the Amaryllidaceae family. The cytotoxicity of all isolated compounds was tested against colorectal carcinoma (HCT 116), breast carcinoma (MCF-7), and non-tumor human retinal pigment epithelium (RPE) cell lines. The half-maximum inhibitory concentration (IC50) of compound 2 against each cell line was equivalent to the positive control (doxorubicin), indicating a considerable cytotoxic activity. Keywords: narciclasine; galasine; cytotoxic activity; absolute configuration; vibrational circular dichroism | - |
| dc.format.extent | 11 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Sociedade Brasileira de Química | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.21577/0103-5053.20200116 | - |
| dc.relation.ispartof | Journal of the Brazilian Chemical Society, 2020, vol. 31, p. 2135-2145 | - |
| dc.relation.uri | https://doi.org/10.21577/0103-5053.20200116 | - |
| dc.rights | cc-by (c) Sociedade Brasileira de Química, 2020 | - |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
| dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
| dc.subject.classification | Alcaloides | - |
| dc.subject.classification | Citotoxicitat per mediació cel·lular | - |
| dc.subject.classification | Dicroisme circular | - |
| dc.subject.classification | Tumors | - |
| dc.subject.other | Alkaloids | - |
| dc.subject.other | Cell-mediated cytotoxicity | - |
| dc.subject.other | Circular dichroism | - |
| dc.subject.other | Tumors | - |
| dc.title | Isolation, absolute configuration and cytotoxic activities of alkaloids from Hippeastrum goianum (Ravenna) Meerow (Amaryllidaceae) | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 710167 | - |
| dc.date.updated | 2021-04-01T11:33:42Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 710167.pdf | 622.04 kB | Adobe PDF | View/Open |
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