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http://hdl.handle.net/2445/175995
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DC Field | Value | Language |
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dc.contributor.author | Marazuela, Paula | - |
dc.contributor.author | Bonaterra Pastra, Anna | - |
dc.contributor.author | Faura, Júlia | - |
dc.contributor.author | Penalba, Anna | - |
dc.contributor.author | Pizarro, Jesús | - |
dc.contributor.author | Pancorbo, Olalla | - |
dc.contributor.author | Rodríguez Luna, David | - |
dc.contributor.author | Vert, Carla | - |
dc.contributor.author | Rovira, Alex | - |
dc.contributor.author | Pujadas, Francesc | - |
dc.contributor.author | Freijo, M. Mar | - |
dc.contributor.author | Tur, Silvia | - |
dc.contributor.author | Martínez Zabaleta, Maite | - |
dc.contributor.author | Cardona Portela, Pere | - |
dc.contributor.author | Vera, Rocío | - |
dc.contributor.author | Lebrato Hernández, Lucia | - |
dc.contributor.author | Arenillas, Juan F. | - |
dc.contributor.author | Pérez Sánchez, Soledad | - |
dc.contributor.author | Montaner, Joan | - |
dc.contributor.author | Delgado, Pilar | - |
dc.contributor.author | Hernández Guillamon, Mar | - |
dc.date.accessioned | 2021-04-07T07:58:24Z | - |
dc.date.available | 2021-04-07T07:58:24Z | - |
dc.date.issued | 2021-03-02 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175995 | - |
dc.description.abstract | Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10050989 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 5 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10050989 | - |
dc.rights | cc by (c) Marazuela et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Hemorràgia | - |
dc.subject.classification | Malalties del sistema nerviós central | - |
dc.subject.classification | Ressonància magnètica | - |
dc.subject.other | Hemorrhage | - |
dc.subject.other | Central nervous system diseases | - |
dc.subject.other | Magnetic resonance | - |
dc.title | Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-03-25T08:16:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33801197 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jcm-10-00989.pdf | 1.04 MB | Adobe PDF | View/Open |
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