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Title: Acute Tubulointerstitial Nephritis in Clinical Oncology: A Comprehensive Review
Author: Martínez Valenzuela, Laura
Draibe, Juliana
Fulladosa, Xavier
Gomà, Montse
Gómez, Francisco
Antón, Paula
Cruzado, Josep Ma.
Torras Ambròs, Joan
Keywords: Insuficiència renal
Renal insufficiency
Issue Date: 26-Feb-2021
Publisher: MDPI
Abstract: Acute kidney injury in patients who suffer a malignancy is a common complication. Due to its high prevalence and effective treatment, one of the most frequent causes that both oncologists and nephrologists must be aware of is acute tubulointerstitial nephritis (ATIN). ATIN is an immunomediated condition and the hallmark of the disease, with the presence of a tubulointerstitial inflammatory infiltrate in the renal parenchyma. This infiltrate is composed mainly of T lymphocytes that can be accompanied by macrophages, neutrophils, or eosinophils among other cells. One of the major causes is drug-related ATIN, and some antineoplastic treatments have been related to this condition. Worthy of note are the novel immunotherapy treatments aimed at enhancing natural immunity in order to defeat cancer cells. In the context of the immunosuppression status affecting ATIN patients, some pathogen antigens can trigger the development of the disease. Finally, hematological malignancies can also manifest in the kidney leading to ATIN, even at the debut of the disease. In this review, we aim to comprehensively examine differential diagnosis of ATIN in the setting of a neoplastic patient.
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It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 5
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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