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http://hdl.handle.net/2445/176032
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DC Field | Value | Language |
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dc.contributor.author | Fragiel, Marcos | - |
dc.contributor.author | Miró i Andreu, Òscar | - |
dc.contributor.author | Llorens, Pere | - |
dc.contributor.author | Jiménez, Sònia | - |
dc.contributor.author | Piñera Salmerón, Pascual | - |
dc.contributor.author | Burillo Putze, Guillermo | - |
dc.contributor.author | Martín, Alfonso | - |
dc.contributor.author | Martín Sánchez, Francisco Javier | - |
dc.contributor.author | García Lamberechts, Eric Jorge | - |
dc.contributor.author | Jacob, Javier | - |
dc.contributor.author | Alquézar Arbé, Aitor | - |
dc.contributor.author | Llopis Roca, Ferran | - |
dc.contributor.author | Pedraza García, Jorge | - |
dc.contributor.author | Calvo López, Ricardo | - |
dc.contributor.author | Maza Vera, María Teresa | - |
dc.contributor.author | Lucas Imbernón, Francisco Javier | - |
dc.contributor.author | González Martinez, Félix | - |
dc.contributor.author | Juárez, Ricardo | - |
dc.contributor.author | Expósito Rodriguez, Marcos | - |
dc.contributor.author | Martinez Bautista, Beatriz Maria | - |
dc.contributor.author | Niembro Valdés, Ana Patricia | - |
dc.contributor.author | Sanchez Nicolas, Jose Andres | - |
dc.contributor.author | Ferreras Amez, José María | - |
dc.contributor.author | Porta Etessam, Jesús | - |
dc.contributor.author | Calvo, Elpidio | - |
dc.contributor.author | González del Castillo, Juan | - |
dc.contributor.author | Spanish Investigators on Emergency Situations TeAm (SIESTA) network | - |
dc.date.accessioned | 2021-04-06T12:57:14Z | - |
dc.date.available | 2021-04-06T12:57:14Z | - |
dc.date.issued | 2021-03-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176032 | - |
dc.description.abstract | We investigated the incidence, clinical characteristics, risk factors, and outcome of meningoencephalitis (ME) in patients with COVID-19 attending emergency departments (ED), before hospitalization. We retrospectively reviewed all COVID patients diagnosed with ME in 61 Spanish EDs (20% of Spanish EDs, COVID-ME) during the COVID pandemic. We formed two control groups: non-COVID patients with ME (non-COVID-ME) and COVID patients without ME (COVID-non-ME). Unadjusted comparisons between cases and controls were performed regarding 57 baseline and clinical characteristics and 4 outcomes. Cerebrospinal fluid (CSF) biochemical and serologic findings of COVID-ME and non-COVID-ME were also investigated. We identified 29 ME in 71,904 patients with COVID-19 attending EDs (0.40‰, 95%CI=0.27-0.58). This incidence was higher than that observed in non-COVID patients (150/1,358,134, 0.11‰, 95%CI=0.09-0.13; OR=3.65, 95%CI=2.45-5.44). With respect to non-COVID-ME, COVID-ME more frequently had dyspnea and chest X-ray abnormalities, and neck stiffness was less frequent (OR=0.3, 95%CI=0.1-0.9). In 69.0% of COVID-ME, CSF cells were predominantly lymphocytes, and SARS-CoV-2 antigen was detected by RT-PCR in 1 patient. The clinical characteristics associated with a higher risk of presenting ME in COVID patients were vomiting (OR=3.7, 95%CI=1.4-10.2), headache (OR=24.7, 95%CI=10.2-60.1), and altered mental status (OR=12.9, 95%CI=6.6-25.0). COVID-ME patients had a higher in-hospital mortality than non-COVID-ME patients (OR=2.26; 95%CI=1.04-4.48), and a higher need for hospitalization (OR=8.02; 95%CI=1.19-66.7) and intensive care admission (OR=5.89; 95%CI=3.12-11.14) than COVID-non-ME patients. ME is an unusual form of COVID presentation (<0.5‰ cases), but is more than 4-fold more frequent than in non-COVID patients attending the ED. As the majority of these MEs had lymphocytic predominance and in one patient SARS-CoV-2 antigen was detected in CSF, SARS-CoV-2 could be the cause of most of the cases observed. COVID-ME patients had a higher unadjusted in-hospital mortality than non-COVID-ME patients. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1007/s10096-021-04206-5 | - |
dc.relation.ispartof | European Journal of Clinical Microbiology & Infectious Diseases, 2021 | - |
dc.relation.uri | https://doi.org/10.1007/s10096-021-04206-5 | - |
dc.rights | (c) Fragiel et al., 2021 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Malalties cerebrals | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Brain diseases | - |
dc.subject.other | SARS-CoV-2 | - |
dc.title | Incidence, clinical characteristics, risk factors and outcomes of meningoencephalitis in patients with COVID-19 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-03-25T07:58:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33686558 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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Fragiel2021_Article_IncidenceClinicalCharacteristi.pdf | 580.97 kB | Adobe PDF | View/Open |
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