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http://hdl.handle.net/2445/176045
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DC Field | Value | Language |
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dc.contributor.author | Dettorre, Gino M. | - |
dc.contributor.author | Dolly, Saoirse | - |
dc.contributor.author | Loizidou, Angela | - |
dc.contributor.author | Chester, John | - |
dc.contributor.author | Jackson, Amanda | - |
dc.contributor.author | Mukherjee, Uma | - |
dc.contributor.author | Zambelli, Alberto | - |
dc.contributor.author | Aguilar Company, Juan | - |
dc.contributor.author | Bower, Mark | - |
dc.contributor.author | Sng, Christopher C. T. | - |
dc.contributor.author | Salazar Soler, Ramón | - |
dc.contributor.author | Bertuzzi, Alexia | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Mesía Nin, Ricard | - |
dc.contributor.author | Sita-Lumsden, Ailsa | - |
dc.contributor.author | Seguí, Elia | - |
dc.contributor.author | Biello, Federica | - |
dc.contributor.author | Generali, Daniele | - |
dc.contributor.author | Grisanti, Salvatore | - |
dc.contributor.author | Seeva, Pavetha | - |
dc.contributor.author | Rizzo, Gianpiero | - |
dc.contributor.author | Libertini, Michela | - |
dc.contributor.author | Maconi, Antonio | - |
dc.contributor.author | Moss, Charlotte | - |
dc.contributor.author | Russell, Beth | - |
dc.contributor.author | Harbeck, Nadia | - |
dc.contributor.author | Vincenzi, Bruno | - |
dc.contributor.author | Bertulli, Rossella | - |
dc.contributor.author | Ottaviani, Diego | - |
dc.contributor.author | Liñan, Raquel | - |
dc.contributor.author | Marrari, Andrea | - |
dc.contributor.author | Carmona García, M. Carmen | - |
dc.contributor.author | Chopra, Neha | - |
dc.contributor.author | Tondini, Carlo Alberto | - |
dc.contributor.author | Mirallas, Oriol | - |
dc.contributor.author | Tovazzi, Valeria | - |
dc.contributor.author | Fotia, Vittoria | - |
dc.contributor.author | Cruz, Claudia Andrea | - |
dc.contributor.author | Saoudi González, Nadia | - |
dc.contributor.author | Felip, Eudald | - |
dc.contributor.author | Roqué, Ariadna | - |
dc.contributor.author | Lee, Alvin J. X. | - |
dc.contributor.author | Newsom-Davis, Tom | - |
dc.contributor.author | García Illescas, David | - |
dc.contributor.author | Reyes, Roxana | - |
dc.contributor.author | Wong, Yien Ning Sophia | - |
dc.contributor.author | Ferrante, Daniela | - |
dc.contributor.author | Scotti, Lorenza | - |
dc.contributor.author | Marco Hernández, Javier | - |
dc.contributor.author | Ruiz Camps, Isabel | - |
dc.contributor.author | Patriarca, Andrea | - |
dc.contributor.author | Rimassa, Lorenza | - |
dc.contributor.author | Chiudinelli, Lorenzo | - |
dc.contributor.author | Franchi, Michela | - |
dc.contributor.author | Santoro, Armando | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Gennari, Alessandra | - |
dc.contributor.author | Van Hemelrijck, Mieke | - |
dc.contributor.author | Tabernero Caturla, Josep | - |
dc.contributor.author | Diamantis, Nikolaos | - |
dc.contributor.author | Pinato, David J. | - |
dc.contributor.author | OnCovid study group | - |
dc.date.accessioned | 2021-04-08T08:49:32Z | - |
dc.date.available | 2021-04-08T08:49:32Z | - |
dc.date.issued | 2021-03-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176045 | - |
dc.description.abstract | Background: Patients with cancer are particularly susceptible to SARS-CoV-2 infection. The systemic inflammatory response is a pathogenic mechanism shared by cancer progression and COVID-19. We investigated systemic inflammation as a driver of severity and mortality from COVID-19, evaluating the prognostic role of commonly used inflammatory indices in SARS-CoV-2-infected patients with cancer accrued to the OnCovid study. Methods: In a multicenter cohort of SARS-CoV-2-infected patients with cancer in Europe, we evaluated dynamic changes in neutrophil:lymphocyte ratio (NLR); platelet:lymphocyte ratio (PLR); Prognostic Nutritional Index (PNI), renamed the OnCovid Inflammatory Score (OIS); modified Glasgow Prognostic Score (mGPS); and Prognostic Index (PI) in relation to oncological and COVID-19 infection features, testing their prognostic potential in independent training (n=529) and validation (n=542) sets. Results: We evaluated 1071 eligible patients, of which 625 (58.3%) were men, and 420 were patients with malignancy in advanced stage (39.2%), most commonly genitourinary (n=216, 20.2%). 844 (78.8%) had ≥1 comorbidity and 754 (70.4%) had ≥1 COVID-19 complication. NLR, OIS, and mGPS worsened at COVID-19 diagnosis compared with pre-COVID-19 measurement (p<0.01), recovering in survivors to pre-COVID-19 levels. Patients in poorer risk categories for each index except the PLR exhibited higher mortality rates (p<0.001) and shorter median overall survival in the training and validation sets (p<0.01). Multivariable analyses revealed the OIS to be most independently predictive of survival (validation set HR 2.48, 95% CI 1.47 to 4.20, p=0.001; adjusted concordance index score 0.611). Conclusions: Systemic inflammation is a validated prognostic domain in SARS-CoV-2-infected patients with cancer and can be used as a bedside predictor of adverse outcome. Lymphocytopenia and hypoalbuminemia as computed by the OIS are independently predictive of severe COVID-19, supporting their use for risk stratification. Reversal of the COVID-19-induced proinflammatory state is a putative therapeutic strategy in patients with cancer. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/jitc-2020-002277 | - |
dc.relation.ispartof | Journal for ImmunoTherapy of Cancer, 2021, vol. 9, num. 3 | - |
dc.relation.uri | https://doi.org/10.1136/jitc-2020-002277 | - |
dc.rights | cc by (c) Dettorre et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | COVID-19 | - |
dc.subject.other | Cancer | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | COVID-19 | - |
dc.title | Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 717453 | - |
dc.date.updated | 2021-04-08T08:02:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33753569 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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e002277.full.pdf | 1.65 MB | Adobe PDF | View/Open |
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