Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176060
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFernández Bañares, Fernando-
dc.contributor.authorCarrasco García, Anna-
dc.contributor.authorRosinach, Mercè-
dc.contributor.authorArau, Beatriz-
dc.contributor.authorGarcía Puig, Roger-
dc.contributor.authorGonzález, Clarisa-
dc.contributor.authorTristán, Eva-
dc.contributor.authorZabana, Yamile-
dc.contributor.authorEsteve i Comas, Maria-
dc.date.accessioned2021-04-08T10:10:53Z-
dc.date.available2021-04-08T10:10:53Z-
dc.date.issued2019-05-10-
dc.identifier.issn2072-6643-
dc.identifier.urihttp://hdl.handle.net/2445/176060-
dc.description.abstractBackground & aims: Determining whether patients with lymphocytic enteritis (LE) have coeliac disease is a challenge. We analysed the variables associated with a low-grade coeliac enteropathy diagnosis in patients with suspected coeliac disease but without villous atrophy, and developed a scoring system to identify them. Methods: We collected data from 2010 through to 2016 on patients with lymphocytic enteritis and persistent symptoms compatible with the clinical spectrum of coeliac disease. One hundred and four patients starting on a gluten-free diet (GFD) were included. Duodenal biopsies were collected before the GFD and analysed for numbers of CD3+ T-cell receptor gamma delta+ (TCRγδ+), and CD3- intraepithelial lymphocytes. We performed a logistic regression analysis to identify factors associated with a low-grade coeliac enteropathy diagnosis. Results: Sixty-two patients achieved clinical remission after the GFD. Fifty of these 62 patients were diagnosed with low-grade coeliac enteropathy. Multivariate analysis identified the presence of >25% intraepithelial lymphocytosis, HLA-DQ2.5, positive serology, and increased numbers of TCRγδ+ cells with a low-grade coeliac enteropathy diagnosis. We developed a scoring system that identified patients with an area under the ROC curve (AUC) of 0.91. Scores of >10 had 86% sensitivity and 85% specificity. Conclusion: We developed a scoring system that identifies patients likely to be diagnosed with low-grade coeliac enteropathy with an AUC value of 0.91.-
dc.format.extent12 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/nu11051050-
dc.relation.ispartofNutrients, 2019, vol. 11, num. 5, p. 1050-
dc.relation.urihttps://doi.org/10.3390/nu11051050-
dc.rightscc-by (c) Fernández Bañares, Fernando et al., 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationMalaltia celíaca-
dc.subject.classificationTerapèutica-
dc.subject.otherCeliac disease-
dc.subject.otherTherapeutics-
dc.titleA Scoring System for Identifying Patients Likely to Be Diagnosed with Low-Grade Coeliac Enteropathy-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec692108-
dc.date.updated2021-04-08T10:10:53Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid31083384-
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
692108.pdf984.23 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons