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dc.contributor.authorFernández Bañares, Fernando-
dc.contributor.authorCarrasco García, Anna-
dc.contributor.authorRosinach, Mercè-
dc.contributor.authorArau, Beatriz-
dc.contributor.authorGarcía Puig, Roger-
dc.contributor.authorGonzález, Clarisa-
dc.contributor.authorTristán, Eva-
dc.contributor.authorZabana, Yamile-
dc.contributor.authorEsteve i Comas, Maria-
dc.description.abstractBackground & aims: Determining whether patients with lymphocytic enteritis (LE) have coeliac disease is a challenge. We analysed the variables associated with a low-grade coeliac enteropathy diagnosis in patients with suspected coeliac disease but without villous atrophy, and developed a scoring system to identify them. Methods: We collected data from 2010 through to 2016 on patients with lymphocytic enteritis and persistent symptoms compatible with the clinical spectrum of coeliac disease. One hundred and four patients starting on a gluten-free diet (GFD) were included. Duodenal biopsies were collected before the GFD and analysed for numbers of CD3+ T-cell receptor gamma delta+ (TCRγδ+), and CD3- intraepithelial lymphocytes. We performed a logistic regression analysis to identify factors associated with a low-grade coeliac enteropathy diagnosis. Results: Sixty-two patients achieved clinical remission after the GFD. Fifty of these 62 patients were diagnosed with low-grade coeliac enteropathy. Multivariate analysis identified the presence of >25% intraepithelial lymphocytosis, HLA-DQ2.5, positive serology, and increased numbers of TCRγδ+ cells with a low-grade coeliac enteropathy diagnosis. We developed a scoring system that identified patients with an area under the ROC curve (AUC) of 0.91. Scores of >10 had 86% sensitivity and 85% specificity. Conclusion: We developed a scoring system that identifies patients likely to be diagnosed with low-grade coeliac enteropathy with an AUC value of 0.91.-
dc.format.extent12 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofNutrients, 2019, vol. 11, num. 5, p. 1050-
dc.rightscc-by (c) Fernández Bañares, Fernando et al., 2019-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationMalaltia celíaca-
dc.subject.otherCeliac disease-
dc.titleA Scoring System for Identifying Patients Likely to Be Diagnosed with Low-Grade Coeliac Enteropathy-
Appears in Collections:Articles publicats en revistes (Medicina)

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