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Title: Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis
Author: Parra Robert, Marina
Casals, Eudald
Massana, Núria
Zeng, Muling
Perramón, Meritxell
Fernández Varo, Guillermo
Morales Ruiz, Manuel
Puntes, Víctor
Jiménez Povedano, Wladimiro
Casals Mercadal, Gregori
Keywords: Malalties del fetge
Àcids grassos
Estrès oxidatiu
Liver diseases
Fatty acids
Oxidative stress
Issue Date: 29-Aug-2019
Publisher: MDPI
Abstract: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related solely to the decrease in oxidative stress or, in addition, they directly decrease liver fatty acid accumulation. To address this question, in this work, we used an in vitro model of hepatocellular steatosis, exposing HepG2 cells to oleic and palmitic acid. Cell uptake of CeO2NPs and their effect on oxidative stress and viability of hepatic cells cultured with H2O2 were also evaluated. Results show that CeO2NPs were uptaken by HepG2 cells and reduced oxidative stress and improved cell viability. Treatment with oleic and palmitic acid increased lipogenesis and the content of different fatty acids. CeO2NPs reduced palmitic and stearic acid and most fatty acids consisting of more than 18 carbon atoms. These effects were associated with significant changes in elongase and desaturase activity. In conclusion, CeO2NPs directly protected HepG2 cells from cell injury in oxidative stress conditions and reduced fatty acid content in steatotic conditions by inducing specific changes in fatty acid metabolism, thus showing potential in the treatment of NAFLD.
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It is part of: Biomolecules, 2019, vol. 9, num. 9, p. 425
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ISSN: 2218-273X
Appears in Collections:Articles publicats en revistes (Biomedicina)

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