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dc.contributor.authorAlmanza Aguilera, Enrique-
dc.contributor.authorHernáez Camba, Álvaro-
dc.contributor.authorCorella Piquer, Dolores-
dc.contributor.authorSanllorente, Albert-
dc.contributor.authorRos Rahola, Emilio-
dc.contributor.authorPortoles, Olga-
dc.contributor.authorValussi, Julieta-
dc.contributor.authorEstruch Riba, Ramon-
dc.contributor.authorColtell, Óscar-
dc.contributor.authorSubirana Cachinero, Isaac-
dc.contributor.authorCanudas Puig, Sílvia-
dc.contributor.authorRazquin, Cristina-
dc.contributor.authorBlanchart, Gemma-
dc.contributor.authorNonell, Lara-
dc.contributor.authorFitó Colomer, Montserrat-
dc.contributor.authorCastañer, Olga-
dc.description.abstractWe aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini-Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant 'upregulation' and ≤ -2.0 'downregulation'). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, -log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, -log(p-value) = 2.03) and paxillin (z-score = 2.33, -log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = -2.14, -log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.-
dc.format.extent12 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofJournal of Clinical Medicine, 2020, vol. 10, num. 1, p. 85-
dc.rightscc-by (c) Almanza Aguilera, Enrique et al., 2020-
dc.sourceArticles publicats en revistes (Medicina)-
dc.subject.classificationDiabetis no-insulinodependent-
dc.subject.classificationCèl·lules T-
dc.subject.otherNon-insulin-dependent diabetes-
dc.subject.otherT cells-
dc.titleCancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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