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http://hdl.handle.net/2445/176075
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DC Field | Value | Language |
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dc.contributor.author | Palmas, Lucia | - |
dc.contributor.author | Aroffu, Matteo | - |
dc.contributor.author | Petretto, Giacomo L. | - |
dc.contributor.author | Escribano Ferrer, Elvira | - |
dc.contributor.author | Díez Sales, Octavio | - |
dc.contributor.author | Usach, Iris | - |
dc.contributor.author | Peris, José Esteban | - |
dc.contributor.author | Marongiu, Francesca | - |
dc.contributor.author | Ghavam, Mansureh | - |
dc.contributor.author | Fais, Sara | - |
dc.contributor.author | Orrù, Germano | - |
dc.contributor.author | Rached, Rita Abi | - |
dc.contributor.author | Manca, Maria Letizia | - |
dc.contributor.author | Manconi, Maria | - |
dc.date.accessioned | 2021-04-08T11:37:13Z | - |
dc.date.available | 2021-04-08T11:37:13Z | - |
dc.date.issued | 2020-08-28 | - |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176075 | - |
dc.description.abstract | This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacterium | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ph13090216 | - |
dc.relation.ispartof | Pharmaceuticals, 2020, vol. 13, num. 9, p. 216 | - |
dc.relation.uri | https://doi.org/10.3390/ph13090216 | - |
dc.rights | cc-by (c) Palmas, Lucia et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Olis essencials | - |
dc.subject.classification | Llimones | - |
dc.subject.classification | Malalties de la boca | - |
dc.subject.classification | Estreptococs | - |
dc.subject.other | Essences and essential oils | - |
dc.subject.other | Lemons | - |
dc.subject.other | Mouth diseases | - |
dc.subject.other | Streptococcus | - |
dc.title | Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707313 | - |
dc.date.updated | 2021-04-08T11:37:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32872140 | - |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
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707313.pdf | 4.4 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License