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Title: Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance
Author: Salvat Pujol, Neus
Labad, Javier
Urretavizcaya Sarachaga, Mikel
Arriba Arnau, Aida de
Segalàs Cosi, Cinto
Real, Eva
Ferrer, Alex
Crespo, José M.
Jiménez-Murcia, Susana
Soriano Mas, Carles
Menchón Magriñá, José Manuel
Soria, Virginia
Keywords: Maltractament infantil
Depressió psíquica
Trastorns cognitius
Child abuse
Cognition disorders
Mental depression
Issue Date: 1-Jan-2021
Publisher: Informa UK Limited
Abstract: Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects.
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It is part of: European Journal of Psychotraumatology, 2021, vol. 12, issue. 1, p. 1857955
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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