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Title: | The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms |
Author: | Benito Hernández, M. Natividad de Mur, Isabel Ribera Puig, Alba Soriano Viladomiu, Alex Rodríguez-Pardo, Dolors Sorli, Luisa Cobo Reinoso, Javier Fernández Sampedro, Marta Toro, Maria Dolores del Guio, Laura Praena Segovia, Julia Bahamonde, Alberto Riera, Melchor Esteban, Jaime Baraia Etxaburu, Josu Martínez-Alvarez, Jesús Jover Sáenz, Alfredo Dueñas, Carlos J. Ramos Martínez, Antonio Sobrino, Beatriz Euba, Gorane Morata, Laura Pigrau, Carles Horcajada Gallego, Juan Pablo Coll, Pere Crusi, Xavier Ariza Cardenal, Javier REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections SEIMC (Spanish Society of Infectious Diseases) |
Keywords: | Infeccions Pròtesis Etiologia Infections Prosthesis Etiology |
Issue Date: | 1-May-2019 |
Publisher: | MDPI |
Abstract: | The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and 'positive intraoperative cultures' (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm8050673 |
It is part of: | Journal of Clinical Medicine, 2019, vol. 8, num. 5, p. 673 |
URI: | http://hdl.handle.net/2445/176155 |
Related resource: | https://doi.org/10.3390/jcm8050673 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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