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Title: The different microbial etiology of prosthetic joint infections according to route of acquisition and time after prosthesis implantation, including the role of multidrug-resistant organisms
Author: Benito Hernández, M. Natividad de
Mur, Isabel
Ribera Puig, Alba
Soriano Viladomiu, Alex
Rodríguez-Pardo, Dolors
Sorli, Luisa
Cobo Reinoso, Javier
Fernández Sampedro, Marta
Toro, Maria Dolores del
Guio, Laura
Praena Segovia, Julia
Bahamonde, Alberto
Riera, Melchor
Esteban, Jaime
Baraia Etxaburu, Josu
Martínez-Alvarez, Jesús
Jover Sáenz, Alfredo
Dueñas, Carlos J.
Ramos Martínez, Antonio
Sobrino, Beatriz
Euba, Gorane
Morata, Laura
Pigrau, Carles
Horcajada Gallego, Juan Pablo
Coll, Pere
Crusi, Xavier
Ariza Cardenal, Javier
REIPI (Spanish Network for Research in Infectious Disease) Group for the Study of Prosthetic Joint Infections
SEIMC (Spanish Society of Infectious Diseases)
Keywords: Infeccions
Issue Date: 1-May-2019
Publisher: MDPI
Abstract: The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)-including multidrug-resistant organisms (MDRO)-by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama's scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and 'positive intraoperative cultures' (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2019, vol. 8, num. 5, p. 673
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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