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Title: | Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis |
Author: | Cobo Dols, Manuel Beato Zambrano, Carmen Cabezón Gutiérrez, Luis Chicas Sett, Rodolfo Blancas López-Barajas, María Isabel García Navalón, Francisco Fírvida Pérez, José Luis Serrano Bermúdez, Gala Togores Torres, Pilar Delgado Mingorance, Ignacio Giraldo Marín, Alexandra Librán Oriol, Anna Paredes Lario, Alfredo Sánchez Mauriño, Pedro Higuera Gómez, Oliver Moreno Muñoz, Diana Jiménez López, Antonio Javier Huerta González, Ibone Sanz Yagüe, Almudena Soler López, Begoña |
Keywords: | Càncer Restrenyiment Opiacis Cancer Constipation Opioids |
Issue Date: | 6-May-2020 |
Publisher: | BMJ |
Abstract: | Objectives: Opioid-induced constipation (OIC) can affect up to 63% of all patients with cancer. The objectives of this study were to assess quality of life as well as efficacy and safety of naloxegol, in patients with cancer with OIC. Methods: An observational study was made of a cohort of patients with cancer and with OIC exhibiting an inadequate response to laxatives and treated with naloxegol. The sample consisted of adult outpatients with a Karnofsky performance status score ≥50. The Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) and the Patient Assessment of Constipation Symptoms (PAC-SYM) were applied for 3 months. Results: A total of 126 patients (58.2% males) with a mean age of 61.3 years (range 34-89) were included. Clinically relevant improvements (>0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p<0.0001) from 15 days of treatment. The number of days a week with complete spontaneous bowel movements increased significantly (p<0.0001) from 2.4 to 4.6 on day 15, 4.7 after 1 month and 5 after 3 months. Pain control significantly improved (p<0.0001) during follow-up. A total of 13.5% of the patients (17/126) presented some gastrointestinal adverse reaction, mostly of mild (62.5%) or moderate intensity (25%). Conclusions: Clinically relevant improvements in OIC-related quality of life, number of bowel movements and constipation-related symptoms were recorded as early as after 15 days of treatment with naloxegol in patients with cancer and OIC, with a good safety profile. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/bmjspcare-2020-002249 |
It is part of: | BMJ Supportive & Palliative Care, 2020, vol. 11, num. 1, p. 25-31 |
URI: | http://hdl.handle.net/2445/176180 |
Related resource: | https://doi.org/10.1136/bmjspcare-2020-002249 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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