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Title: Effects of Bifidobacterium animalis Subsp. lactis (BPL1) Supplementation in Children and Adolescents with Prader-Willi Syndrome: A Randomized Crossover Trial
Author: Amat Bou, Montse
García Ribera, Sonika
Climent, Eric
Piquer García, Irene
Corripio, Raquel
Sánchez Infantes, David
Villalta, Laia
Elias, María
Jiménez Chillarón, Josep C.
Chenoll, Empar
Ramón, Daniel
Ibáñez Toda, Lourdes
Ramón Krauel, Marta
Lerin, Carles
Keywords: Síndrome de Prader-Willi
Microbiota intestinal
Prader-Willi syndrome
Gastrointestinal microbiome
Issue Date: 13-Oct-2020
Publisher: MDPI
Abstract: Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by a wide range of clinical manifestations, including obesity, hyperphagia, and behavioral problems. Bifidobacterium animalis subsp. lactis strain BPL1 has been shown to improve central adiposity in adults with simple obesity. To evaluate BPL1's effects in children with PWS, we performed a randomized crossover trial among 39 patients (mean age 10.4 years). Participants were randomized to placebo-BPL1 (n = 19) or BPL1-placebo (n = 20) sequences and underwent a 12-week period with placebo/BPL1 treatments, a 12-week washout period, and a 12-week period with the crossover treatment. Thirty-five subjects completed the study. The main outcome was changes in adiposity, measured by dual-energy X-ray absorptiometry. Secondary outcomes included lipid and glucose metabolism, hyperphagia, and mental health symptoms. Generalized linear modeling was applied to assess differences between treatments. While BPL1 did not modify total fat mass compared to placebo, BPL1 decreased abdominal adiposity in a subgroup of patients older than 4.5 years (n = 28). BPL1 improved fasting insulin concentration and insulin sensitivity. Furthermore, we observed modest improvements in some mental health symptoms. A follow-up trial with a longer treatment period is warranted to determine whether BPL1 supplementation can provide a long-term therapeutic approach for children with PWS ( NCT03548480).
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2020, vol. 12, num. 10, p. 3123
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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