Please use this identifier to cite or link to this item:
Title: Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy
Author: Alves de Lima Jr., Edson
de Souza Teixeira, Alexandre Abilio
Amorim Biondo, Luana
Aparecido Diniz, Tiego
Sanches Silveira, Loreana
Coletti, Dario
Busquets Rius, Sílvia
Rosa Neto, José Cesar
Keywords: Etiologia
Càncer de pulmó
Lung cancer
Issue Date: 20-Nov-2020
Publisher: MDPI
Abstract: The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed to evaluate the effects of endurance exercise on time-dependent muscle atrophy caused by doxorubicin. For this, C57 BL/6 mice were subcutaneously inoculated with Lewis lung carcinoma cells (LLC group). One week after the tumor establishment, a group of these animals initiated the doxorubicin chemotherapy alone (LLC + DOX group) or combined with endurance exercise (LLC + DOX + EXER group). One group of animals was euthanized after the chemotherapy cycle, whereas the remaining animals were euthanized one week after the last administration of doxorubicin. The practice of exercise combined with chemotherapy showed beneficial effects such as a decrease in tumor growth rate after chemotherapy interruption and amelioration of premature death due to doxorubicin toxicity. Moreover, the protein degradation levels in mice undergoing exercise returned to basal levels after chemotherapy; in contrast, the mice treated with doxorubicin alone experienced an increase in the mRNA expression levels of the proteolytic pathways in gastrocnemius muscle (Trim63, Fbxo32, Myostatin, FoxO). Collectively, our results suggest that endurance exercise could be utilized during and after chemotherapy for mitigating muscle atrophy promoted by doxorubicin and avoid the resumption of tumor growth.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2020, vol. 12, num. 11, p. 3466
Related resource:
ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
708982.pdf1.95 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons