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Title: Economic burden of recurrent Clostridioides difficile infection in adults admitted to Spanish hospitals. A multicentre retrospective observational study
Author: Bouza, Emilio
Cobo Reinoso, Javier
Rodríguez Hernández, María Jesús
Salavert, Miguel
Horcajada Gallego, Juan Pablo
Iribarren, José A.
Obi, Engels
López, Virginia
Maratia, Stefano
Cuesta, Maribel
Uría, Estefany
Limón, Enrique
Keywords: Bacteris
Issue Date: 1-Apr-2021
Publisher: Sociedad Española de Quimioterapia
Abstract: Objective: Clostridioides difficile infection (CDI) is associated with increased hospital stays and mortality and a high likelihood of rehospitalization, leading to increased health resource use and costs. The objective was to estimate the economic burden of recurrent CDI (rCDI). Methods: observational, retrospective study carried out in six hospitals. Adults aged ≥18 years with ≥1 confirmed diagnosis (primary or secondary) of rCDI between January 2010 and May 2018 were included. rCDI-related resource use included days of hospital stay (emergency room, ward, isolation and ICU), tests and treatments. For patients with primary diagnosis of rCDI, the complete hospital stay was attributed to rCDI. When diagnosis of rCDI was secondary, hospital stay attributed to rCDI was estimated using 1:1 propensity score matching as the difference in hospital stay compared to controls. Controls were hospitalizations without CDI recorded in the Spanish National Hospital Discharge Database. The cost was calculated by multiplying the natural resource units by the unit cost. Costs (euros) were updated to 2019. Results: we included 282 rCDI episodes (188 as primary diagnosis): 66.31% of patients were aged ≥65 years and 57.80% were female. The mean hospital stay (SD) was 17.18 (23.27) days: 86.17% of rCDI episodes were isolated for a mean (SD) of 10.30 (9.97) days. The total mean cost (95%-CI) per episode was 10,877 (9,499-12,777), of which the hospital stay accounted for 92.56. Conclusions: there is high cost and resource use associated with rCDI, highlighting the importance of preventing rCDI to the Spanish National Health System.
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It is part of: Revista Espanola de Quimioterapia, 2021, vol. 34, num. 2, p. 126-135
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ISSN: 0214-3429
Appears in Collections:Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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