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DC Field | Value | Language |
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dc.contributor.author | Lope, Virginia | - |
dc.contributor.author | Guerrero Zotano, Ángel | - |
dc.contributor.author | Casas, Ana | - |
dc.contributor.author | Baena Cañada, José Manuel | - |
dc.contributor.author | Bermejo, Begona | - |
dc.contributor.author | Pérez Gómez, Beatriz | - |
dc.contributor.author | Criado Navarro, Inmaculada | - |
dc.contributor.author | Antolín, Silvia | - |
dc.contributor.author | Sánchez Rovira, Pedro | - |
dc.contributor.author | Ramos Vázquez, Manuel | - |
dc.contributor.author | Antón, Antonio | - |
dc.contributor.author | Castelló, Adela | - |
dc.contributor.author | García Saenz, Jose Angel | - |
dc.contributor.author | Muñoz Mateu, Montserrat | - |
dc.contributor.author | Juan, Ana de | - |
dc.contributor.author | Andrés, Raquel | - |
dc.contributor.author | Llombart Cussac, Antonio | - |
dc.contributor.author | Hernando, Blanca | - |
dc.contributor.author | Franquesa, Rosa María | - |
dc.contributor.author | Caballero, Rosalía | - |
dc.contributor.author | Priego Capote, Feliciano | - |
dc.contributor.author | Martón, Miguel | - |
dc.contributor.author | Pollán, Marina | - |
dc.date.accessioned | 2021-04-15T11:30:28Z | - |
dc.date.available | 2021-04-15T11:30:28Z | - |
dc.date.issued | 2020-10-01 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176311 | - |
dc.description.abstract | This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu12103132 | - |
dc.relation.ispartof | Nutrients, 2020, vol. 12, num. 10 | - |
dc.relation.uri | https://doi.org/10.3390/nu12103132 | - |
dc.rights | cc-by (c) Lope, Virginia et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Àcids grassos | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Fatty acids | - |
dc.title | Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709554 | - |
dc.date.updated | 2021-04-15T11:30:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33066483 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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709554.pdf | 535.67 kB | Adobe PDF | View/Open |
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