Por favor, use este identificador para citar o enlazar este documento: https://hdl.handle.net/2445/176323
Título: Systemic Inflammation during and after Bronchiectasis Exacerbations: Impact of Pseudomonas aeruginosa
Autor: Menéndez, Rosario
Méndez, Raúl
Amara Elori, Isabel
Reyes, Soledad
Montull, Beatriz
Feced, Laura
Alonso, Ricardo
Amaro, Rosanel
Alcaraz Serrano, Victoria
Fernández Barat, Laia
Torres Martí, Antoni
Materia: Malalties cròniques
Citoquines
Chronic diseases
Cytokines
Fecha de publicación: 13-agoo-2020
Publicado por: MDPI
Resumen: Bronchiectasis is a chronic structural disease associated with exacerbations that provoke systemic inflammation. We aimed to evaluate the systemic acute proinflammatory cytokine and its biomarker profiles during and after exacerbations and its relationship with the severity of episode, microbiological findings, and the bronchiectasis severity index. This prospective observational study compared exacerbation and stable groups. Cytokine (interleukins (IL)-17a, IL-1β, IL-6, IL 8; tumor necrosis factor-alpha (α)) and high-sensitivity C-reactive protein (hsCRP) levels were determined by multiplex analysis on days 1, 5, 30, and 60 in the exacerbation group and on day 1 in the stable group. We recruited 165 patients with exacerbations, of which 93 were severe (hospitalized). Proinflammatory systemic IL-17a, IL-1β, IL-8, and tumor necrosis factor-α levels increased similarly on days 1 and 5 in severe and non-severe episodes, but on day 30, IL-17a, IL-8, and IL-6 levels were only increased for severe exacerbations. The highest IL-17a level occurred in patients with chronic plus the acute isolation of Pseudomonas aeruginosa. At 30 days, severe exacerbations were independently associated with higher levels of IL-17 (Odds ratio (OR) 4.58), IL-6 (OR 4.89), IL-8 (OR 3.08), and hsCRP (OR 6.7), adjusted for age, the bronchiectasis severity index, and treatment duration. Exacerbations in patients with chronic P. aeruginosa infection were associated with an increase in IL-17 and IL-6 at 30 days (ORs 7.47 and 3.44, respectively). Severe exacerbations elicit a higher systemic proinflammatory response that is sustained to day 30. Patients with chronic P. aeruginosa infection had impaired IL-17a reduction. IL-17a could be a useful target for measuring systemic inflammation.
Nota: Reproducció del document publicat a: https://doi.org/10.3390/jcm9082631
Es parte de: Journal of Clinical Medicine, 2020, vol. 9, num. 8, p. 2631
URI: https://hdl.handle.net/2445/176323
Recurso relacionado: https://doi.org/10.3390/jcm9082631
ISSN: 2077-0383
Aparece en las colecciones:Articles publicats en revistes (Medicina)

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