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Title: A data independent acquisition all ion fragmentation mode tool for the suspect screening of natural toxins in surface water
Author: Picardo, Massimo
Núñez Burcio, Oscar
Farré, Marinella
Keywords: Toxines
Ecologia d'aigua dolça
Espectrometria de masses
Freshwater ecology
Mass spectrometry
Issue Date: 19-Feb-2021
Publisher: Elsevier
Abstract: Among natural freshwater pollutants, cyanotoxins, mycotoxins, and phytotoxins are the most important and less studied. Their identification in surface water is challenging especially cause of the lack of standards and established analytical parameters. Most target methods focus one or a single group of compounds with similar characteristics. Here we present an AIF fast method for the tentative identification of natural toxins in water. Respect to the previous method [1], it offers higher performances for the acquisition of unknown compounds at low levels for higher number of analytes.The key aspects of the method are: -The qualitative screening DIA-AIF workflow using Q Exactive Orbitrap. Both targeted and suspect screening bases have been combined with online databases and suspect list to retrieve candidates as suspect natural toxins and their metabolites or degradation products. -The in-silico analysis of mass spectrums allowed a fast structural characterization. -The workflow has been finally applied to real samples coming from the Czech Republic, Italy, and Spain allowing the determination of 17 suspect natural toxins, 4 of them confirmed. None toxin passed the limit of 1 µg/L taken from the legislation applied for microcystin LR and arbitrarily extended to all toxins.
Note: Reproducció del document publicat a:
It is part of: MethodsX, 2021, vol. 8, p. 101286
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ISSN: 2215-0161
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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