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http://hdl.handle.net/2445/176615
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DC Field | Value | Language |
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dc.contributor.author | Martínez-Florensa, Mario | - |
dc.contributor.author | Català, Cristina | - |
dc.contributor.author | Velasco de Andrés, María | - |
dc.contributor.author | Cañadas, Olga | - |
dc.contributor.author | Fraile Ágreada, Víctor | - |
dc.contributor.author | Casadó Llombart, Sergi | - |
dc.contributor.author | Armiger Borràs, Noelia | - |
dc.contributor.author | Consuegra-Fernández, Marta | - |
dc.contributor.author | Casals, Cristina | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.date.accessioned | 2021-04-22T09:50:18Z | - |
dc.date.available | 2021-04-22T09:50:18Z | - |
dc.date.issued | 2018-04-12 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176615 | - |
dc.description.abstract | Sepsis is an unmet clinical need constituting one of the most important causes of death worldwide, a fact aggravated by the appearance of multidrug resistant strains due to indiscriminate use of antibiotics. Host innate immune receptors involved in pathogen-associated molecular patterns (PAMPs) recognition represent a source of broad-spectrum therapies alternative or adjunctive to antibiotics. Among the few members of the ancient and highly conserved scavenger receptor cysteine-rich superfamily (SRCR-SF) sharing bacterial-binding properties there is CD6, a lymphocyte-specific surface receptor. Here, we analyze the bacterial-binding properties of three conserved short peptides (11-mer) mapping at extracellular SRCR domains of human CD6 (CD6.PD1, GTVEVRLEASW; CD6.PD2 GRVEMLEHGEW; and CD6.PD3, GQVEVHFRGVW). All peptides show high binding affinity for PAMPs from Gram-negative (lipopolysaccharide; Kd from 3.5 to 3,000 nM) and Gram-positive (lipoteichoic acid; Kd from 36 to 680 nM) bacteria. The CD6.PD3 peptide possesses broad bacterial-agglutination properties and improved survival of mice undergoing polymicrobial sepsis in a dose- and time-dependent manner. Accordingly, CD6.PD3 triggers a decrease in serum levels of both pro-inflammatory cytokines and bacterial load. Interestingly, CD6.PD3 shows additive survival effects on septic mice when combined with Imipenem/Cilastatin. These results illustrate the therapeutic potential of peptides retaining the bacterial-binding properties of native CD6. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2018.00627 | - |
dc.relation.ispartof | Frontiers in Immunology, 2018, vol. 9, p. 627 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2018.00627 | - |
dc.rights | cc-by (c) Martínez Florensa, Mario et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Septicèmia | - |
dc.subject.classification | Immunitat | - |
dc.subject.classification | Cisteïna | - |
dc.subject.other | Septicemia | - |
dc.subject.other | Immunity | - |
dc.subject.other | Cysteine | - |
dc.title | Conserved bacterial-binding peptides of the scavenger-like lymphocyte receptor CD6 protect from mouse experimental sepsis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 692390 | - |
dc.date.updated | 2021-04-22T09:50:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29706953 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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692390.pdf | 5.32 MB | Adobe PDF | View/Open |
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