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Title: Contribution of CSF biomarkers to early-onset Alzheimer's disease and frontotemporal dementia neuroimaging signatures
Author: Falgàs Martínez, Neus
Ruiz Peris, Mariona
Pérez Millán, Agnès
Sala Llonch, Roser
Antonell, Anna
Balasa, Mircea
Borrego Écija, Sergi
Ramos Campoy, Oscar
Augé Fradera, Josep Maria
Castellví, Magdalena
Tort Merino, Adrià
Olives, Jaume
Fernández Villullas, Guadalupe
Blennow, Kaj
Zetterberg, Henrik
Bargalló Alabart, Núria​
Lladó Plarrumaní, Albert
Sánchez Valle, Raquel
Keywords: Malaltia d'Alzheimer
Líquid cefalorraquidi
Alzheimer's disease
Cerebrospinal fluid
Issue Date: 16-Jan-2020
Publisher: Wiley
Abstract: Prior studies have described distinct patterns of brain gray matter and white matter alterations in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD), as well as differences in their cerebrospinal fluid (CSF) biomarkers profiles. We aim to investigate the relationship between early‐onset AD (EOAD) and FTLD structural alterations and CSF biomarker levels. We included 138 subjects (64 EOAD, 26 FTLD, and 48 controls), all of them with a 3T MRI brain scan and CSF biomarkers available (the 42 amino acid‐long form of the amyloid‐beta protein [Aβ42], total‐tau protein [T‐tau], neurofilament light chain [NfL], neurogranin [Ng], and 14‐3‐3 levels). We used FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. We studied group differences in CTh and FA and described the "AD signature" and "FTLD signature." We tested multiple regression models to find which CSF‐biomarkers better explained each disease neuroimaging signature. CTh and FA maps corresponding to the AD and FTLD signatures were in accordance with previous literature. Multiple regression analyses showed that the biomarkers that better explained CTh values within the AD signature were Aβ and 14‐3‐3; whereas NfL and 14‐3‐3 levels explained CTh values within the FTLD signature. Similarly, NfL levels explained FA values in the FTLD signature. Ng levels were not predictive in any of the models. Biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.
Note: Reproducció del document publicat a:
It is part of: Human Brain Mapping, 2020, vol. 41, num. 8, p. 2004-2013
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ISSN: 1065-9471
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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