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Title: Adequacy of early-stage breast cancer systemic adjuvant treatment to Saint Gallen-2013 statement: the MCC-Spain study
Author: Gómez Acebo, Inés
Dierssen Sotos, Trinidad
Mirones, Mónica
Pérez Gómez, Beatriz
Guevara, Marcela
Amiano, Pilar
Sala, Maria
Molina de la Torre, Antonio José
Alonso Molero, Jéssica
Moreno Aguado, Víctor
Suarez Calleja, Claudia
Molina Barceló, Ana
Alguacil, Juan
Marcos Gragera, Rafael
Fernández Ortiz, María
Sanz Guadarrama, Oscar
Castaño-Vinyals, Gemma
Gil Majuelo, Leire
Moreno Iribas, Conchi
Aragonès Sanz, Núria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Keywords: Càncer de mama
Tractament adjuvant del càncer
Breast cancer
Adjuvant treatment of cancer
Issue Date: 8-Mar-2021
Publisher: Springer Nature
Abstract: The St Gallen Conference endorsed in 2013 a series of recommendations on early breast cancer treatment. The main purpose of this article is to ascertain the clinical factors associated with St Gallen-2013 recommendations accomplishment. A cohort of 1152 breast cancer cases diagnosed with pathological stage < 3 in Spain between 2008 and 2013 was begun and then followed-up until 2017/2018. Data on patient and tumour characteristics were obtained from medical records, as well as their first line treatment. First line treatments were classified in three categories, according on whether they included the main St Gallen-2013 recommendations, more than those recommended or less than those recommended. Multinomial logistic regression models were carried out to identify factors associated with this classification and Weibull regression models were used to find out the relationship between this classification and survival. About half of the patients were treated according to St Gallen recommendations; 21% were treated over what was recommended and 33% received less treatment than recommended. Factors associated with treatment over the recommendations were stage II (relative risk ratio [RRR] = 4.2, 2.9-5.9), cancer positive to either progesterone (RRR = 8.1, 4.4-14.9) or oestrogen receptors (RRR = 5.7, 3.0-11.0). Instead, factors associated with lower probability of treatment over the recommendations were age (RRR = 0.7 each 10 years, 0.6-0.8), poor differentiation (RRR = 0.09, 0.04-0.19), HER2 positive (RRR = 0.46, 0.26-0.81) and triple negative cancer (RRR = 0.03, 0.01-0.11). Patients treated less than what was recommended in St Gallen had cancers in stage 0 (RRR = 21.6, 7.2-64.5), poorly differentiated (RRR = 1.9, 1.2-2.9), HER2 positive (RRR = 3.4, 2.4-4.9) and luminal B-like subtype (RRR = 3.6, 2.6-5.1). Women over 65 years old had a higher probability of being treated less than what was recommended if they had luminal B-like, HER2 or triple negative cancer. Treatment over St Gallen was associated with younger women and less severe cancers, while treatment under St Gallen was associated with older women, more severe cancers and cancers expressing HER2 receptors.
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It is part of: Scientific Reports, 2021, vol. 11
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Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

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