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Title: Adenosine A2A receptors are upregulated in peripheral blood mononuclear cells from atrial fibrillation patients
Author: Godoy-Marín, Héctor
Duroux, Romain
Jacobson, Kenneth A.
Soler Prat, Concepció
Colino-Lage, Hildegard
Jiménez-Sábado, Veronica
Montiel, José
Hove-Madsen, Leif
Ciruela Alférez, Francisco
Keywords: Adenosina
Fibril·lació auricular
Nuclis cel·lulars
Atrial fibrillation
Cell nuclei
Issue Date: 27-Mar-2021
Publisher: MDPI
Abstract: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia seen in clinical practice. While some clinical parameters may predict the transition from paroxysmal to persistent AF, the molecular mechanisms behind the AF perpetuation are poorly understood. Thus, oxidative stress, calcium overload and inflammation, among others, are believed to be involved in AF-induced atrial remodelling. Interestingly, adenosine and its receptors have also been related to AF development and perpetuation. Here, we investigated the expression of adenosine A2A receptor (A2AR) both in right atrium biopsies and peripheral blood mononuclear cells (PBMCs) from non-dilated sinus rhythm (ndSR), dilated sinus rhythm (dSR) and AF patients. In addition, plasma adenosine content and adenosine deaminase (ADA) activity in these subjects were also determined. Our results revealed increased A2AR expression in the right atrium from AF patients, as previously described. Interestingly, increased levels of adenosine content and reduced ADA activity in plasma from AF patients were detected. An increase was observed when A2AR expression was assessed in PBMCs from AF subjects. Importantly, a positive correlation (P=0.001) between A2AR expression in the right atrium and PBMCs was observed. Overall, these results highlight the importance of the A2AR in AF and suggest that the evaluation of this receptor in PBMCs may be potentially be useful in monitoring disease severity and the efficacy of pharmacological treatments in AF patients.
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It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 7, p. 3467
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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