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http://hdl.handle.net/2445/176712
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DC Field | Value | Language |
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dc.contributor.author | Choi, Jee-Eun | - |
dc.contributor.author | Sebastian, Carlos | - |
dc.contributor.author | Ferrer, Christina M. | - |
dc.contributor.author | Lewis, Caroline A. | - |
dc.contributor.author | Sade Feldman, Moshe | - |
dc.contributor.author | LaSalle, Thomas | - |
dc.contributor.author | Gonye, Anna | - |
dc.contributor.author | Lopez, Begona G. C. | - |
dc.contributor.author | Abdelmoula, Walid M. | - |
dc.contributor.author | Regan, Michael S. | - |
dc.contributor.author | Cetinbas, Murat | - |
dc.contributor.author | Pascual, Gloria | - |
dc.contributor.author | Wojtkiewicz, Gregory R. | - |
dc.contributor.author | Silveira, Giorgia G. | - |
dc.contributor.author | Boon, Ruben | - |
dc.contributor.author | Ross, Kenneth N. | - |
dc.contributor.author | Tirosh, Itary | - |
dc.contributor.author | Saladi, Srinivas V. | - |
dc.contributor.author | Ellisen, Leif W. | - |
dc.contributor.author | Sadreyev, Ruslan I. | - |
dc.contributor.author | Aznar Benitah, Salvador | - |
dc.contributor.author | Agar, Nathalie Y. R. | - |
dc.contributor.author | Hacohen, Nir | - |
dc.contributor.author | Mostoslavsky, Raúl | - |
dc.date.accessioned | 2021-04-26T10:02:42Z | - |
dc.date.available | 2021-08-22T05:10:20Z | - |
dc.date.issued | 2021-02-22 | - |
dc.identifier.issn | 2522-5812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176712 | - |
dc.description.abstract | Head and neck squamous cell carcinoma (SCC) remains among the most aggressive human cancers. Tumour progression and aggressiveness in SCC are largely driven by tumour-propagating cells (TPCs). Aerobic glycolysis, also known as the Warburg effect, is a characteristic of many cancers; however, whether this adaptation is functionally important in SCC, and at which stage, remains poorly understood. Here, we show that the NAD+-dependent histone deacetylase sirtuin 6 is a robust tumour suppressor in SCC, acting as a modulator of glycolysis in these tumours. Remarkably, rather than a late adaptation, we find enhanced glycolysis specifically in TPCs. More importantly, using single-cell RNA sequencing of TPCs, we identify a subset of TPCs with higher glycolysis and enhanced pentose phosphate pathway and glutathione metabolism, characteristics that are strongly associated with a better antioxidant response. Together, our studies uncover enhanced glycolysis as a main driver in SCC, and, more importantly, identify a subset of TPCs as the cell of origin for the Warburg effect, defining metabolism as a key feature of intra-tumour heterogeneity. | ca |
dc.format.extent | 13 | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Springer Nature | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/s42255-021-00350-6 | - |
dc.relation.ispartof | Nature Metabolism, 2021, Vol. 3, num. 2, p. 182-195 | - |
dc.relation.uri | https://doi.org/10.1038/s42255-021-00350-6 | - |
dc.rights | (c) Springer Nature, 2021 | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Càncer de coll | - |
dc.subject.classification | Càncer de cap | - |
dc.subject.classification | Proliferació cel·lular | - |
dc.subject.other | Neck cancer | - |
dc.subject.other | Head cancer | - |
dc.subject.other | Cell proliferation | - |
dc.title | A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2021-04-26T08:54:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6479539 | - |
dc.identifier.pmid | 33619381 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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12541_6479539_choi_et_al-combined_nature_metabolism_s.aznar_2021.pdf | 2.47 MB | Adobe PDF | View/Open |
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